TY - GEN
T1 - Free fatty acid profile in type 2 diabetic subjects with different control of glycemia
AU - Mandal, S.
AU - Causevic, A.
AU - Dzudzevic-Cancar, H.
AU - Semiz, S.
N1 - Publisher Copyright:
© Springer Nature Singapore Pte Ltd. 2017.
PY - 2017
Y1 - 2017
N2 - Type 2 diabetes (T2D) as a multifactorial disease is characterized not only by chronic hyperglycaemia but also with defects in lipid and protein metabolism. These defects impact the utilization of glucose and non-esterified “free“ fatty acids (NEFA) by muscle, liver, and adipose tissue. Free fatty acids (FFA) represent an important link between obesity, insulin resistance, and T2D. Eleveted plasma concentration of FFA (especially saturated FFA) is associated with impaired insulin secretion and sensitivity and glucose intolerance. The major objective of the present study was to investigate association of plasma free fatty acid profile in Type 2 diabetic subjects with different control of glycemia. This study involved 40 patients with T2D and 40 healthy subjects. Preparation of samples for FFA analysis was done by extraction and methanolysis of plasma lipids while detection and quantification of FFA concentrations was done by gas chromatography/mass spectrometry. Other biochemical analyses, including glucose, glycated hemoglobin (HbA1c), cholesterol, and triglycerides were done according to standard IFCC methods. A significant difference between T2D and control subjects was demonstrated only for palmitic acid (C16:0). There was a significant correlation of C16:0 with HbA1c levels (p<0.001) in patients with both adequate and poor T2D control. Also, a significant correlation was obtained at a level of plasma C18:1(p<0,05) and HbA1c level, only in patients with inadequate diabetes control. Thus, our data suggested that palmitic fatty acid (C16:0) and (C18:1) could serve as a potential biomarkers in optimal T2D management.
AB - Type 2 diabetes (T2D) as a multifactorial disease is characterized not only by chronic hyperglycaemia but also with defects in lipid and protein metabolism. These defects impact the utilization of glucose and non-esterified “free“ fatty acids (NEFA) by muscle, liver, and adipose tissue. Free fatty acids (FFA) represent an important link between obesity, insulin resistance, and T2D. Eleveted plasma concentration of FFA (especially saturated FFA) is associated with impaired insulin secretion and sensitivity and glucose intolerance. The major objective of the present study was to investigate association of plasma free fatty acid profile in Type 2 diabetic subjects with different control of glycemia. This study involved 40 patients with T2D and 40 healthy subjects. Preparation of samples for FFA analysis was done by extraction and methanolysis of plasma lipids while detection and quantification of FFA concentrations was done by gas chromatography/mass spectrometry. Other biochemical analyses, including glucose, glycated hemoglobin (HbA1c), cholesterol, and triglycerides were done according to standard IFCC methods. A significant difference between T2D and control subjects was demonstrated only for palmitic acid (C16:0). There was a significant correlation of C16:0 with HbA1c levels (p<0.001) in patients with both adequate and poor T2D control. Also, a significant correlation was obtained at a level of plasma C18:1(p<0,05) and HbA1c level, only in patients with inadequate diabetes control. Thus, our data suggested that palmitic fatty acid (C16:0) and (C18:1) could serve as a potential biomarkers in optimal T2D management.
KW - Control of glycemia
KW - Free fatty acid
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85016012771&partnerID=8YFLogxK
U2 - 10.1007/978-981-10-4166-2_117
DO - 10.1007/978-981-10-4166-2_117
M3 - Conference contribution
AN - SCOPUS:85016012771
SN - 9789811041655
T3 - IFMBE Proceedings
SP - 781
EP - 786
BT - CMBEBIH 2017 - Proceedings of the International Conference on Medical and Biological Engineering, 2017
A2 - Badnjevic, Almir
PB - Springer Verlag
T2 - International Conference on Medical and Biological Engineering, CMBEBIH 2017
Y2 - 16 March 2017 through 18 March 2017
ER -
