First one-pot organocatalytic synthesis of α-methylene-γ-lactones

Xavier Companyó, Andrea Mazzanti, Albert Moyano, Anna Janeck, Ramon Rios

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


All in one pot: an organocatalytic highly enantioselective synthesis of α-methylene-β-lactones has been reported. The reaction between protected 2-hydroxymalonates and MBH carbonates is simply catalysed by chiral Lewis bases affording after acid treatment the corresponding lactones in excellent yields and enantioselectivities.

Original languageBritish English
Pages (from-to)1184-1186
Number of pages3
JournalChemical Communications
Issue number12
StatePublished - 1 Jan 2013


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