Facile preparation of a cellulose microfibers–exfoliated graphite composite: a robust sensor for determining dopamine in biological samples

Selvakumar Palanisamy, Pan Yi-Fan, Shen Ming Chen, Vijayalakshmi Velusamy, James M. Hall

    Research output: Contribution to journalArticlepeer-review

    10 Scopus citations

    Abstract

    A simple and robust dopamine (DA) sensor was developed using a cellulose microfibers (CMF)–exfoliated graphite composite-modified screen-printed carbon electrode (SPCE) for the first time. The graphite-CMF composite was prepared by sonication of pristine graphite in CMF solution and was characterized by high-resolution scanning electron microscopy, Fourier transform, infrared, and Raman spectroscopy. The cyclic voltammetry results reveal that the graphite-CMF composite modified SPCE has superior electrocatalytic activity against oxidation of dopamine than SPCE modified with pristine graphite and CMF. The presence of large edge plane defects on exfoliated graphite and abundant oxygen functional groups of CMF enhance electrocatalytic activity and decrease potential to oxidize DA. Differential pulse voltammetry was used to quantify DA using the graphite-CMF composite-modified SPCE and demonstrated a linear response for DA detection in the range of 0.06–134.5 µM. The sensor shows a detection limit at 10 nM with an appropriate sensitivity and displays appropriate recovery of DA in human serum samples with good repeatability. Sensor selectivity is demonstrated in the presence of 50-fold concentrations of potentially active interfering compounds including ascorbic acid, uric acid, and dihydroxybenzene isomers.

    Original languageBritish English
    Pages (from-to)4291-4302
    Number of pages12
    JournalCellulose
    Volume24
    Issue number10
    DOIs
    StatePublished - 1 Oct 2017

    Keywords

    • Cellulose microfibers
    • Dopamine
    • Electrochemical sensor
    • Exfoliated graphite
    • Functional composite

    Fingerprint

    Dive into the research topics of 'Facile preparation of a cellulose microfibers–exfoliated graphite composite: a robust sensor for determining dopamine in biological samples'. Together they form a unique fingerprint.

    Cite this