Fabrication of large-area ordered and reproducible nanostructures for SERS biosensor application

Gobind Das, Niranjan Patra, Anisha Gopalakrishnan, Remo Proietti Zaccaria, Andrea Toma, Sanjay Thorat, Enzo Di Fabrizio, Alberto Diaspro, Marco Salerno

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


We propose a large-area SERS device with efficient fluorescence quenching capability. The substrate is based on anodic porous alumina templates with various pore size and wall thickness as small as 15 and 36 nm, respectively. The nano-patterned SERS substrate, with excellent control and reproducibility of plasmon-polaritons generation, shows very efficient enhanced Raman signal in the presence of intrinsically fluorescent molecules such as cresyl violet, rhodamine, and green fluorescent protein. This work demonstrates that, when the nanostructures are properly designed and fabricated, Raman and fluorescence spectroscopy can be used in combination in order to obtain complementary molecular informations. Theoretical simulation shows excellent agreement with the experimental findings. The enhancement factor is found to be 10 3-104, with respect to flat gold surface when the molecules are supposed to be closely packed, with considerable fluorescence suppression, showing a promising disposable biosensor.

Original languageBritish English
Pages (from-to)1785-1792
Number of pages8
Issue number8
StatePublished - 21 Apr 2012


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