Fabrication of colloidal silver-peptide nanocomposites for bacterial wound healing

Muhammad Ovais, Arbab Ali, Sana Ullah, Ali Talha Khalil, Atia Atiq, Maria Atiq, Nurcan Dogan, Zabta Khan Shinwari, Manzar Abbas

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Increased antibiotic resistance has become a real healthcare challenge for humanity. Several novel approaches for the formation of nanomaterials have been developed to tackle different bacterial strains and wound disinfection. Short peptide modulated metal nanomaterials have gained attention because of their biocompatibility and ability to reduce metal ions in-situ to form nanoparticles. Here we have used a short peptide conjugate as a reducing and capping agent to make stabilized silver-peptide composite nanoparticles under mild UV light exposure. This photochemical method is one of the green approaches and reduces the toxic effects of chemicals that are often used in traditional synthetic strategies. These composite nanoparticles demonstrated promising activity against Escherichia coli and Staphylococcus aureus at an in-vitro level and have the ability to cure wounds disinfections in-vivo. Furthermore, these composite nanoparticles show excellent biocompatibility, and no side effects were observed in liver enzymes and organs, in a histopathology study. Such a simple strategy of sustainable supramolecular chemistry could help develop novel nanomaterials as potential antibiotic agents of the future.

Original languageBritish English
Article number129708
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume651
DOIs
StatePublished - 20 Oct 2022

Keywords

  • Antibacterial
  • In-vivo wound healing
  • Metal-composites
  • Short peptide
  • Wound disinfection

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