TY - JOUR
T1 - Fabrication of Chitosan/PVA/GO/CuO patch for potential wound healing application
AU - Venkataprasanna, K. S.
AU - Prakash, J.
AU - Vignesh, S.
AU - Bharath, G.
AU - Venkatesan, Manigandan
AU - Banat, Fawzi
AU - Sahabudeen, S.
AU - Ramachandran, Saravanan
AU - Devanand Venkatasubbu, G.
N1 - Funding Information:
The authors K.S. Venkataprasanna and G. Devanand Venkatasubbu thanks SRM Research Institute for providing the Raman and TEM facilities.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/1/15
Y1 - 2020/1/15
N2 - Wound healing is a common issue in our day to day life. Our immune system repairs the damaged tissue by itself and its a time-consuming process. The GO/CuO nanocomposite (NC) was synthesized through the sol-gel method. XRD, FT-IR, Raman, and TEM analysis were used to analysis the physico-chemical properties of the sample. The GO/CuO patches were prepared using chitosan (Cs)/poly vinyl alcohol (PVA) due to its biocompatibility and biodegradable nature. The obtained patches showed better antimicrobial and wound healing property than recently reported materials. The GO/CuO NC plays a major part in angiogenesis process and in the synthesis, stabilization of extracellular matrix skin proteins. Thus, GO/CuO NC enhance the wound healing mechanism by increasing cell proliferation, antimicrobial property and rapid initiation of inflammatory. Moreover, the antimicrobial activity of CuO, GO, GO/CuO and GO/CuO patch were tested against bacteria causing wound infections. Cs/PVA patch and Cs/PVA/GO/CuO patch were analyzed for swelling, evaporation and degradation behavior. Increase in cell viability and migration of NIH3t3 cells by NC patch shows a potential way for wound healing applications.
AB - Wound healing is a common issue in our day to day life. Our immune system repairs the damaged tissue by itself and its a time-consuming process. The GO/CuO nanocomposite (NC) was synthesized through the sol-gel method. XRD, FT-IR, Raman, and TEM analysis were used to analysis the physico-chemical properties of the sample. The GO/CuO patches were prepared using chitosan (Cs)/poly vinyl alcohol (PVA) due to its biocompatibility and biodegradable nature. The obtained patches showed better antimicrobial and wound healing property than recently reported materials. The GO/CuO NC plays a major part in angiogenesis process and in the synthesis, stabilization of extracellular matrix skin proteins. Thus, GO/CuO NC enhance the wound healing mechanism by increasing cell proliferation, antimicrobial property and rapid initiation of inflammatory. Moreover, the antimicrobial activity of CuO, GO, GO/CuO and GO/CuO patch were tested against bacteria causing wound infections. Cs/PVA patch and Cs/PVA/GO/CuO patch were analyzed for swelling, evaporation and degradation behavior. Increase in cell viability and migration of NIH3t3 cells by NC patch shows a potential way for wound healing applications.
KW - Antimicrobial activity
KW - Chitosan
KW - Wound healing
UR - https://www.scopus.com/pages/publications/85075403684
U2 - 10.1016/j.ijbiomac.2019.10.029
DO - 10.1016/j.ijbiomac.2019.10.029
M3 - Article
C2 - 31622704
AN - SCOPUS:85075403684
SN - 0141-8130
VL - 143
SP - 744
EP - 762
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -