TY - JOUR
T1 - Extraneural cholinergic markers in Alzheimer's and Parkinson's disease
AU - Adem, Abdu
AU - Nordberg, Agneta
AU - Bucht, Gösta
AU - Winblad, Bengt
N1 - Funding Information:
This study was supported by grants from the Swedish Medical Research Council (No 5817, 56641, the Swedish Tobacco Company and the Loo and Hans Ostermans Foundation. We thank Mrs. Barbro Synnergren and Mrs. Birgitta CIhmanf or their technichal assistance.
PY - 1986
Y1 - 1986
N2 - Adem, Abdu, Agneta Nordberg, Gösta Bucht and Bengt Winblad: Extraneural cholinergic markers in Alzheimer's and Parkinson's disease. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1986, 10 (3-5): 247-257. 1. 1. Muscarinic and nicotinic binding sites were analysed in lymphocytes from patients with Alzheimer's disease, Multi-infarct dementia, Parkinson's disease and age- matched controls. 2. 2. A significant decrease in the number of both muscarinic and nicotinic binding sites was obtained in lymphocytes from Alzheimer patients while in Parkinson patients a significant decrease was found only in the nicotinic binding sites. 3. 3. Using butyrylthiocholine as substrate, no change was observed in cholinesterase activity in plasma from Alzheimer patients, whereas a significant decrease in plasma cholinesterase activity was found in Parkinson patients.
AB - Adem, Abdu, Agneta Nordberg, Gösta Bucht and Bengt Winblad: Extraneural cholinergic markers in Alzheimer's and Parkinson's disease. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1986, 10 (3-5): 247-257. 1. 1. Muscarinic and nicotinic binding sites were analysed in lymphocytes from patients with Alzheimer's disease, Multi-infarct dementia, Parkinson's disease and age- matched controls. 2. 2. A significant decrease in the number of both muscarinic and nicotinic binding sites was obtained in lymphocytes from Alzheimer patients while in Parkinson patients a significant decrease was found only in the nicotinic binding sites. 3. 3. Using butyrylthiocholine as substrate, no change was observed in cholinesterase activity in plasma from Alzheimer patients, whereas a significant decrease in plasma cholinesterase activity was found in Parkinson patients.
KW - Alzheimer's disease
KW - choline acetyltransferase
KW - cholinesterase
KW - Multi-infarct dementia
KW - muscarinic receptors
KW - nicotinic receptors
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=0023007981&partnerID=8YFLogxK
U2 - 10.1016/0278-5846(86)90005-9
DO - 10.1016/0278-5846(86)90005-9
M3 - Article
C2 - 3797683
AN - SCOPUS:0023007981
SN - 0278-5846
VL - 10
SP - 247
EP - 257
JO - Progress in Neuropsychopharmacology and Biological Psychiatry
JF - Progress in Neuropsychopharmacology and Biological Psychiatry
IS - 3-5
ER -