Expression of MHC class II, CD4+ and ED1 molecules in association with selective hippocampal neuronal degeneration after long-term adrenalectomy

Atiqul Islam, Maha Mustafa, Amged Mustafa, Tomas Olsson, Bengt Winblad, Abdu Adem

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The neuroendocrine and the immune systems are interconnected. Monoclonal antibodies against major histocompatibility complex (MHC) class I, class II, CD4, CD8, pan T cells, and macrophages were used for immunostaining brains from adrenalectomized (ADX) and sham-operated rats to investigate the potential involvement of the immune/inflammatory mechanisms in the neurodegeneration of hippocampus after ADX. Our results demonstrate upregulation of MHC class II, CD4 antigens and activated microglial marker-ED1 expression selectively in the hippocampus after ADX. The absence of CD5 reactivity precludes that these activated cells were T lymphocytes. The activated microglial cells may either be instrumental in the hippocampal neuronal loss or activated secondarily to the neuronal degeneration after long-term adrenalectomy.

Original languageBritish English
Pages (from-to)987-990
Number of pages4
JournalNeuroReport
Volume8
Issue number4
DOIs
StatePublished - 1997

Keywords

  • Adrenalectomy
  • Hippocampus
  • Inflammation
  • Major histocompatibility complex antigens
  • Microglia
  • Neurodegeneration
  • Rat

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