Exploring the Potential of Stem Cell-Based Therapy for Aesthetic and Plastic Surgery

Dang Khoa Tran, Thuy Nguyen Thi Phuong, Nhat Le Bui, Vijai Singh, Qi Hao Looi, Benson Koh, Ungku Mohd Shahrin B.Mohd Zaman, Jhi Biau Foo, Chia Ching Wu, Pau Loke Show, Dinh Toi Chu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Over the last decade, stem cell-associated therapies are widely used because of their potential in self-renewable and multipotent differentiation ability. Stem cells have become more attractive for aesthetic uses and plastic surgery, including scar reduction, breast augmentation, facial contouring, hand rejuvenation, and anti-aging. The current preclinical and clinical studies of stem cells on aesthetic uses also showed promising outcomes. Adipose-derived stem cells are commonly used for fat grafting that demonstrated scar improvement, anti-aging, skin rejuvenation properties, etc. While stem cell-based products have yet to receive approval from the FDA for aesthetic medicine and plastic surgery. Moving forward, the review on the efficacy and potential of stem cell-based therapy for aesthetic and plastic surgery is limited. In the present review, we discuss the current status and recent advances of using stem cells for aesthetic and plastic surgery. The potential of cell-free therapy and tissue engineering in this field is also highlighted. The clinical applications, advantages, and limitations are also discussed. This review also provides further works that need to be investigated to widely apply stem cells in the clinic, especially in aesthetic and plastic contexts.

Original languageBritish English
Pages (from-to)386-402
Number of pages17
JournalIEEE Reviews in Biomedical Engineering
StatePublished - 2023


  • aesthetic medicine
  • clinical applications
  • grafting
  • plastic surgery
  • self-renewable
  • Stem cells


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