Examples of catalytic asymmetric amine synthesis using organic catalysts

Ramon Rios, Armando Córdova

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


The asymmetric construction of optically active amine compounds is of paramount interest for the chemical industry and academic research. This review describes the use of catalytic asymmetric transformations, such as Mannich-type, Michael, cycloaddition and transfer-hydrogenation reactions using small organic molecules (eg, amino acids, secondary amines, peptides, thioureas and phosphoric acids) as catalysts, for the construction of important compounds for medicinal chemistry that exhibit anticancer, antibiotic or antiviral activity.

Original languageBritish English
Pages (from-to)824-847
Number of pages24
JournalCurrent Opinion in Drug Discovery and Development
Issue number6
StatePublished - Nov 2009


  • [3+2] cycloaddition
  • Aldehyde
  • Amino acid
  • Asymmetric catalysis
  • Aza-Michael reaction
  • Chiral amine
  • Imine reduction
  • Ketone
  • Mannich reaction
  • Organocatalysis


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