Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis

Herbert F. Jelinek; Helmut Ahammer; Slade Matthews; Peter Succar; Craig S. McLachlan; Michael Buckland

doi:10.2316/P.2012.764-039

Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis

Herbert F. Jelinek
, Helmut Ahammer
, Slade Matthews
, Peter Succar
, Craig S. McLachlan
, Michael Buckland

Biomedical Engineering & Biotechnology

Medical University of Graz
University of Sydney
University of New South Wales
Royal Prince Alfred Hospital

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

Gliomas are the most common type of brain tumours in adults and a significant cause of cancer-related mortality. The lp/19q chromosome deleted oligodendroglioma subtype has been shown to have a good prognosis following chemotherapy. However the subjectivity inherent with associated tissue features in classifying this tumour has led to some uncertainly in diagnosis and identifying optimal treatment options. This study investigated the use of the Higuchi dimension (D _H) as a diagnostic tool to differentiate between the oligodendrogliomas with and without loss of heterozygosity (LOH & noLOH respectively). Sixty-five neurosurgical resection specimens were analysed. D _H was lower in the LOH tissue (mean±sd; 1.69±0.01; CI: 1.69-1.71; p<0.05) compared to the non-deletion group (1.83±0.04; CI: 1.81-1.85; p<0.05). Our results indicate that oligodendroglioma tissue showed scale invariance and that the complexity of the tissue as determined by the Higuchi dimension decreased with loss of genetic heterozygosity. Determination of the fractal dimension of gliomas provides an inexpensive and accurate alternative for classification of oligodendrogliomas.

Original language	British English
Title of host publication	Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012
Pages	25-28
Number of pages	4
DOIs	https://doi.org/10.2316/P.2012.764-039
State	Published - 2012
Event	9th IASTED International Conference on Biomedical Engineering, BioMed 2012 - Innsbruck, Austria Duration: 15 Feb 2012 → 17 Feb 2012

Publication series

Name	Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012

Conference

Conference	9th IASTED International Conference on Biomedical Engineering, BioMed 2012
Country/Territory	Austria
City	Innsbruck
Period	15/02/12 → 17/02/12

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Classification
Cluster analysis
Fractal dimension
Higuchi dimension
Oligodendroglioma

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10.2316/P.2012.764-039

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Cite this

Jelinek, H. F., Ahammer, H., Matthews, S., Succar, P., McLachlan, C. S., & Buckland, M. (2012). Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis. In Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012 (pp. 25-28). (Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012). https://doi.org/10.2316/P.2012.764-039

Jelinek, Herbert F. ; Ahammer, Helmut ; Matthews, Slade et al. / Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis. Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012. 2012. pp. 25-28 (Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012).

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abstract = "Gliomas are the most common type of brain tumours in adults and a significant cause of cancer-related mortality. The lp/19q chromosome deleted oligodendroglioma subtype has been shown to have a good prognosis following chemotherapy. However the subjectivity inherent with associated tissue features in classifying this tumour has led to some uncertainly in diagnosis and identifying optimal treatment options. This study investigated the use of the Higuchi dimension (D H) as a diagnostic tool to differentiate between the oligodendrogliomas with and without loss of heterozygosity (LOH \& noLOH respectively). Sixty-five neurosurgical resection specimens were analysed. D H was lower in the LOH tissue (mean±sd; 1.69±0.01; CI: 1.69-1.71; p<0.05) compared to the non-deletion group (1.83±0.04; CI: 1.81-1.85; p<0.05). Our results indicate that oligodendroglioma tissue showed scale invariance and that the complexity of the tissue as determined by the Higuchi dimension decreased with loss of genetic heterozygosity. Determination of the fractal dimension of gliomas provides an inexpensive and accurate alternative for classification of oligodendrogliomas.",

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author = "Jelinek, \{Herbert F.\} and Helmut Ahammer and Slade Matthews and Peter Succar and McLachlan, \{Craig S.\} and Michael Buckland",

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Jelinek, HF, Ahammer, H, Matthews, S, Succar, P, McLachlan, CS & Buckland, M 2012, Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis. in Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012. Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012, pp. 25-28, 9th IASTED International Conference on Biomedical Engineering, BioMed 2012, Innsbruck, Austria, 15/02/12. https://doi.org/10.2316/P.2012.764-039

Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis. / Jelinek, Herbert F.; Ahammer, Helmut; Matthews, Slade et al.
Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012. 2012. p. 25-28 (Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Succar, Peter

AU - McLachlan, Craig S.

AU - Buckland, Michael

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AB - Gliomas are the most common type of brain tumours in adults and a significant cause of cancer-related mortality. The lp/19q chromosome deleted oligodendroglioma subtype has been shown to have a good prognosis following chemotherapy. However the subjectivity inherent with associated tissue features in classifying this tumour has led to some uncertainly in diagnosis and identifying optimal treatment options. This study investigated the use of the Higuchi dimension (D H) as a diagnostic tool to differentiate between the oligodendrogliomas with and without loss of heterozygosity (LOH & noLOH respectively). Sixty-five neurosurgical resection specimens were analysed. D H was lower in the LOH tissue (mean±sd; 1.69±0.01; CI: 1.69-1.71; p<0.05) compared to the non-deletion group (1.83±0.04; CI: 1.81-1.85; p<0.05). Our results indicate that oligodendroglioma tissue showed scale invariance and that the complexity of the tissue as determined by the Higuchi dimension decreased with loss of genetic heterozygosity. Determination of the fractal dimension of gliomas provides an inexpensive and accurate alternative for classification of oligodendrogliomas.

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ER -

Jelinek HF, Ahammer H, Matthews S, Succar P, McLachlan CS, Buckland M. Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis. In Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012. 2012. p. 25-28. (Proceedings of the 9th IASTED International Conference on Biomedical Engineering, BioMed 2012). doi: 10.2316/P.2012.764-039

Establishing a reference range for oligodendroglioma classification using Higuchi dimension analysis

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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