Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Y. Fatieiev; J. G. Croissant; K. Julfakyan; L. Deng; D. H. Anjum; A. Gurinov; N. M. Khashab

doi:10.1039/c5nr03065j

Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Y. Fatieiev
, J. G. Croissant
, K. Julfakyan
, L. Deng
, D. H. Anjum
, A. Gurinov
, N. M. Khashab

Physics

King Abdullah University of Science and Technology

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

Original language	British English
Pages (from-to)	15046-15050
Number of pages	5
Journal	Nanoscale
Volume	7
Issue number	37
DOIs	https://doi.org/10.1039/c5nr03065j
State	Published - 7 Oct 2015

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title = "Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging",

abstract = "We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50\%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.",

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AU - Fatieiev, Y.

AU - Croissant, J. G.

AU - Julfakyan, K.

AU - Deng, L.

AU - Anjum, D. H.

AU - Gurinov, A.

AU - Khashab, N. M.

PY - 2015/10/7

Y1 - 2015/10/7

N2 - We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

AB - We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

UR - https://www.scopus.com/pages/publications/84942134519

U2 - 10.1039/c5nr03065j

DO - 10.1039/c5nr03065j

M3 - Article

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AN - SCOPUS:84942134519

SN - 2040-3364

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SP - 15046

EP - 15050

JO - Nanoscale

JF - Nanoscale

IS - 37

ER -

Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Abstract

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