Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Y. Fatieiev, J. G. Croissant, K. Julfakyan, L. Deng, D. H. Anjum, A. Gurinov, N. M. Khashab

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

Original languageBritish English
Pages (from-to)15046-15050
Number of pages5
JournalNanoscale
Volume7
Issue number37
DOIs
StatePublished - 7 Oct 2015

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