Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Y. Fatieiev; J. G. Croissant; K. Julfakyan; L. Deng; D. H. Anjum; A. Gurinov; N. M. Khashab

doi:10.1039/c5nr03065j

Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Y. Fatieiev, J. G. Croissant, K. Julfakyan, L. Deng, D. H. Anjum, A. Gurinov, N. M. Khashab

Physics

King Abdullah University of Science and Technology

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

Original language	British English
Pages (from-to)	15046-15050
Number of pages	5
Journal	Nanoscale
Volume	7
Issue number	37
DOIs	https://doi.org/10.1039/c5nr03065j
State	Published - 7 Oct 2015

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abstract = "We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.",

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AU - Fatieiev, Y.

AU - Croissant, J. G.

AU - Julfakyan, K.

AU - Deng, L.

AU - Anjum, D. H.

AU - Gurinov, A.

AU - Khashab, N. M.

PY - 2015/10/7

Y1 - 2015/10/7

N2 - We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

AB - We describe biodegradable bridged silsesquioxane (BS) composite nanomaterials with an unusually high organic content (ca. 50%) based on oxamide components mimicking amino acid biocleavable groups. Unlike most bulk BS materials, the design of sub-200 nm nearly monodisperse nanoparticles (NPs) was achieved. These enzymatically degradable BS NPs were further tested as promising imaging nanoprobes.

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Enzymatically degradable hybrid organic-inorganic bridged silsesquioxane nanoparticles for in vitro imaging

Abstract

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