Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection

Narjes Saheb Sharif-Askari; Fatemeh Saheb Sharif-Askari; Bushra Mdkhana; Saba Al Heialy; Habiba S. Alsafar; Rifat Hamoudi; Qutayba Hamid; Rabih Halwani

doi:10.1016/j.omtm.2020.11.002

Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection

Narjes Saheb Sharif-Askari
, Fatemeh Saheb Sharif-Askari
, Bushra Mdkhana
, Saba Al Heialy
, Habiba S. Alsafar
, Rifat Hamoudi
, Qutayba Hamid
, Rabih Halwani

Biomedical Engineering & Biotechnology

College of Medicine
Mohammed Bin Rashid University of Medicine and Health Sciences
Meakins-Christie Laboratories
King Saud University

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

The immune system is tightly regulated by the activity of stimulatory and inhibitory immune receptors. Using gene expression datasets, Halwani and coworkers showed a pattern of overall upregulation of immune inhibitor receptors on different myeloid and lymphoid cells during SARS-CoV-2 infection. This dysregulation may contribute to the immunopathology and severity of COVID-19.

Original language	British English
Pages (from-to)	109-121
Number of pages	13
Journal	Molecular Therapy - Methods and Clinical Development
Volume	20
DOIs	https://doi.org/10.1016/j.omtm.2020.11.002
State	Published - 12 Mar 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CEACAM1
COVID-19
immune checkpoint inhibitors
immune inhibitory receptors
influenza A virus
lung autopsies
respiratory viral infection
SARS-CoV-2
sialic acid
SIGLEC10

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10.1016/j.omtm.2020.11.002

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title = "Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection",

abstract = "The immune system is tightly regulated by the activity of stimulatory and inhibitory immune receptors. Using gene expression datasets, Halwani and coworkers showed a pattern of overall upregulation of immune inhibitor receptors on different myeloid and lymphoid cells during SARS-CoV-2 infection. This dysregulation may contribute to the immunopathology and severity of COVID-19.",

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note = "Funding Information: This work was supported by a Tissue Injury and Repair Group (TIR Group) operational grant (code 150317 ), COVID-19 research grants ( CoV19-0307 and CoV19-0308 ), and a seed grant (code 2001090275 ); by a collaborative research grant (code 2001090278 ) to R.H., University of Sharjah, UAE ; by a Sandooq Al Watan Applied Research \& Development Grant to R.H. ( SWARD-S20-007 ); by an Al Jalila Foundation Seed Grant ( AJF202019 ); and by the Prince Abdullah Ben Khalid Celiac Disease Research Chair , under the Vice Deanship of Research Chairs, King Saud University, Riyadh, Kingdom of Saudi Arabia . Publisher Copyright: {\textcopyright} 2020 The Authors",

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AU - Saheb Sharif-Askari, Fatemeh

AU - Mdkhana, Bushra

AU - Al Heialy, Saba

AU - Alsafar, Habiba S.

AU - Hamoudi, Rifat

AU - Hamid, Qutayba

AU - Halwani, Rabih

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KW - immune inhibitory receptors

KW - influenza A virus

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KW - SARS-CoV-2

KW - sialic acid

KW - SIGLEC10

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JO - Molecular Therapy - Methods and Clinical Development

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ER -

Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection

Abstract

UN SDGs

Keywords

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