Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection

Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Habiba S. Alsafar, Rifat Hamoudi, Qutayba Hamid, Rabih Halwani

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

The immune system is tightly regulated by the activity of stimulatory and inhibitory immune receptors. Using gene expression datasets, Halwani and coworkers showed a pattern of overall upregulation of immune inhibitor receptors on different myeloid and lymphoid cells during SARS-CoV-2 infection. This dysregulation may contribute to the immunopathology and severity of COVID-19.

Original languageBritish English
Pages (from-to)109-121
Number of pages13
JournalMolecular Therapy - Methods and Clinical Development
Volume20
DOIs
StatePublished - 12 Mar 2021

Keywords

  • CEACAM1
  • COVID-19
  • immune checkpoint inhibitors
  • immune inhibitory receptors
  • influenza A virus
  • lung autopsies
  • respiratory viral infection
  • SARS-CoV-2
  • sialic acid
  • SIGLEC10

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