TY - JOUR
T1 - Enhanced drug delivery, mechanical properties and antimicrobial activities in poly(lactic acid) nanofiber with mesoporous Fe3O4-COOH nanoparticles
AU - Han, Chao
AU - Cai, Ning
AU - Chan, Vincent
AU - Liu, Mingming
AU - Feng, Xiaojuan
AU - Yu, Faquan
N1 - Funding Information:
This research was supported by National Natural Science Foundation of China (21571147), Innovative Team Program of the Natural Science Foundation of Hubei Province (2014CFA011), Innovative Team Incubation Program in High-Tech Industry of Wuhan City (2014070504020244), Natural Science Foundation of Hubei Province (2015CFB430), Hubei Collaborative Innovation Center for Down-Streaming Products in Ethylene Project and Process Intensification and Graduate Innovative Fund of Wuhan Institute of Technology (CX2017139). Vincent Chan was partially supported by CIRA-2018-02 from Khalifa University of Science and Technology.
Publisher Copyright:
© 2018
PY - 2018/12/20
Y1 - 2018/12/20
N2 - A facile strategy to incorporate dual sustained-release system in electrospun poly(lactic acid) (PLA) nanofibers is proposed for emerging applications in advanced drug delivery. Firstly, a model antimicrobial therapeutics, tetracycline hydrochloride (TCH) was blended with Fe3O4-COOH nanoparticles via electrostatic interaction to form novel composite nanoparticles. Then the influence of Fe3O4-COOH or TCH/Fe3O4-COOH nanoparticle incorporation on the morphology, porosity and hydrophilicity of electrospun PLA nanofiber membranes were elucidated. By studying drug release profiles, the newly designed TCH/Fe3O4-COOH/PLA nanofibrous membrane exhibited an obvious transition of drug release mechanisms from zero order release kinetics within the initial 6 days to modulated release beyond 6 days (until 14 days) in PBS. In contrast, TCH/Fe3O4-COOH and TCH/PLA nanofibrous membrane display single mechanism of burst like release within 3.5 days and 2.5 days, respectively. The Young's modulus, tensile strength and toughness of TCH/Fe3O4-COOH/PLA nanofibers are increased by 191%, 150% and 223%, respectively, compared with those of plain PLA electrospun nanofibers. Most importantly, TCH/Fe3O4-COOH/PLA nanofibrous membrane exhibited significantly stronger antibacterial activities against E. coli and S. aureus compared to TCH/Fe3O4-COOH and TCH/PLA nanofibrous membrane. The improved mechanical performance and sustained drug release behavior on TCH/Fe3O4-COOH/PLA pave the way for the emerging applications in drug delivery and tissue engineering.
AB - A facile strategy to incorporate dual sustained-release system in electrospun poly(lactic acid) (PLA) nanofibers is proposed for emerging applications in advanced drug delivery. Firstly, a model antimicrobial therapeutics, tetracycline hydrochloride (TCH) was blended with Fe3O4-COOH nanoparticles via electrostatic interaction to form novel composite nanoparticles. Then the influence of Fe3O4-COOH or TCH/Fe3O4-COOH nanoparticle incorporation on the morphology, porosity and hydrophilicity of electrospun PLA nanofiber membranes were elucidated. By studying drug release profiles, the newly designed TCH/Fe3O4-COOH/PLA nanofibrous membrane exhibited an obvious transition of drug release mechanisms from zero order release kinetics within the initial 6 days to modulated release beyond 6 days (until 14 days) in PBS. In contrast, TCH/Fe3O4-COOH and TCH/PLA nanofibrous membrane display single mechanism of burst like release within 3.5 days and 2.5 days, respectively. The Young's modulus, tensile strength and toughness of TCH/Fe3O4-COOH/PLA nanofibers are increased by 191%, 150% and 223%, respectively, compared with those of plain PLA electrospun nanofibers. Most importantly, TCH/Fe3O4-COOH/PLA nanofibrous membrane exhibited significantly stronger antibacterial activities against E. coli and S. aureus compared to TCH/Fe3O4-COOH and TCH/PLA nanofibrous membrane. The improved mechanical performance and sustained drug release behavior on TCH/Fe3O4-COOH/PLA pave the way for the emerging applications in drug delivery and tissue engineering.
KW - Composite nanofiber
KW - Electrospinning
KW - Iron oxide nanoparticles
KW - Mechanical properties
KW - Poly(lactic acid)
KW - Sustained drug release
UR - https://www.scopus.com/pages/publications/85053538804
U2 - 10.1016/j.colsurfa.2018.09.012
DO - 10.1016/j.colsurfa.2018.09.012
M3 - Article
AN - SCOPUS:85053538804
SN - 0927-7757
VL - 559
SP - 104
EP - 114
JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects
JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects
ER -