Engineering of Brome mosaic virus for biomedical applications

Ibrahim Yildiz; Irina Tsvetkova; Amy M. Wen; Sourabh Shukla; M. Hema Masarapu; Bogdan Dragnea; Nicole F. Steinmetz

doi:10.1039/c2ra01376b

Engineering of Brome mosaic virus for biomedical applications

Ibrahim Yildiz, Irina Tsvetkova, Amy M. Wen, Sourabh Shukla, M. Hema Masarapu, Bogdan Dragnea, Nicole F. Steinmetz

Chemistry

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP Brome mosaic virus (BMV). Functional BMV nanoparticles displaying multiple copies of fluorescent dyes, PEG molecules, chemotherapeutic drug moieties, targeting proteins and cell penetrating peptides were formulated. This opens the door for the application of BMV in nanomedicine.

Original language	British English
Pages (from-to)	3670-3677
Number of pages	8
Journal	RSC Advances
Volume	2
Issue number	9
DOIs	https://doi.org/10.1039/c2ra01376b
State	Published - 21 Apr 2012

Access to Document

10.1039/c2ra01376b

Cite this

@article{71a212ce2ee64db295992ab2a25a526d,

title = "Engineering of Brome mosaic virus for biomedical applications",

abstract = "Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP Brome mosaic virus (BMV). Functional BMV nanoparticles displaying multiple copies of fluorescent dyes, PEG molecules, chemotherapeutic drug moieties, targeting proteins and cell penetrating peptides were formulated. This opens the door for the application of BMV in nanomedicine.",

author = "Ibrahim Yildiz and Irina Tsvetkova and Wen, {Amy M.} and Sourabh Shukla and Masarapu, {M. Hema} and Bogdan Dragnea and Steinmetz, {Nicole F.}",

year = "2012",

month = apr,

day = "21",

doi = "10.1039/c2ra01376b",

language = "British English",

volume = "2",

pages = "3670--3677",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "9",

}

TY - JOUR

T1 - Engineering of Brome mosaic virus for biomedical applications

AU - Yildiz, Ibrahim

AU - Tsvetkova, Irina

AU - Wen, Amy M.

AU - Shukla, Sourabh

AU - Masarapu, M. Hema

AU - Dragnea, Bogdan

AU - Steinmetz, Nicole F.

PY - 2012/4/21

Y1 - 2012/4/21

N2 - Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP Brome mosaic virus (BMV). Functional BMV nanoparticles displaying multiple copies of fluorescent dyes, PEG molecules, chemotherapeutic drug moieties, targeting proteins and cell penetrating peptides were formulated. This opens the door for the application of BMV in nanomedicine.

AB - Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP Brome mosaic virus (BMV). Functional BMV nanoparticles displaying multiple copies of fluorescent dyes, PEG molecules, chemotherapeutic drug moieties, targeting proteins and cell penetrating peptides were formulated. This opens the door for the application of BMV in nanomedicine.

UR - http://www.scopus.com/inward/record.url?scp=84863098901&partnerID=8YFLogxK

U2 - 10.1039/c2ra01376b

DO - 10.1039/c2ra01376b

M3 - Article

AN - SCOPUS:84863098901

SN - 2046-2069

VL - 2

SP - 3670

EP - 3677

JO - RSC Advances

JF - RSC Advances

IS - 9

ER -

Engineering of Brome mosaic virus for biomedical applications

Abstract

Access to Document

Other files and links

Fingerprint

Cite this