Enantioselective Synthesis of all Carbon Spiro Compounds

Ramon Rios

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


This chapter provides a detailed view of the more important reactions to obtain all-carbon spiro compounds. It focuses on the enantioselective methodologies based on the strategy for the synthesis of the spiro compounds. The chapter presents the strategies for the synthesis of spiro compounds in six different approaches: alkylation strategies, metal-catalyzed methods, ring closure methods, cycloaddition strategies, cascade reactions strategies, and rearrangement strategies. Alkylation methodologies are one of the most common resources to synthesize cyclic compounds by organic chemists. Metal- catalyzedreactions have been one of the classic approaches for the development of new scaffolds in synthetic chemistry. The chapter highlights some examples of its applications for the synthesis of spiro compounds. Cycloadditions have been a common approach for the synthesis of spiro compounds. The chapter presents the use of [2+2+2], Diels Alder, or 3+2 cycloadditions to synthesize spiro scaffolds with good selectivity degrees.

Original languageBritish English
Title of host publicationSpiro Compounds
Subtitle of host publicationSynthesis and Applications
Number of pages30
ISBN (Electronic)9781119567646
ISBN (Print)9781119567639
StatePublished - 1 Jan 2021


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