Enantioselective organocatalytic synthesis of fluorinated molecules

Guillem Valero, Xavier Companyó, Ramon Rios

Research output: Contribution to journalReview articlepeer-review

196 Scopus citations

Abstract

The enantioselective synthesis of fluorinated molecules has drawn much attention within the chemical community due to its unique stereoelectronic properties. The main aim of this review is to cover the most important organocatalytic enantioselective methodologies to obtain them. The review is divided into three parts: first, the direct introduction of a fluorine atom studied in the early 2000s. Second, the later use of Michael reactions to introduce fluorine-containing synthons. Finally, the simultaneously-developed trifluoromethylation reactions, giving the catalysts, mechanisms and reagents that have been used.

Original languageBritish English
Pages (from-to)2018-2037
Number of pages20
JournalChemistry - A European Journal
Volume17
Issue number7
DOIs
StatePublished - 11 Feb 2011

Keywords

  • enamines
  • fluorine
  • Michael reaction
  • organocatalysis
  • trifluoromethylation

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