Enantioselective organocatalytic Mannich reactions of ferrocenecarbaldehyde

Guillem Valero; Andrea Nekane Balaguer; Albert Moyano; Ramon Rios

doi:10.1016/j.tetlet.2008.09.012

Enantioselective organocatalytic Mannich reactions of ferrocenecarbaldehyde

Guillem Valero
, Andrea Nekane Balaguer
, Albert Moyano
, Ramon Rios

Chemistry

Universitat de Barcelona

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The first examples of highly enantioselective organocatalytic Mannich reactions of ferrocenecarbaldehyde are disclosed. The reaction is catalyzed by simple amino acids and gives access to β-arylamino-β-ferrocenylketones in high yields and with up to 99% ee.

Original language	British English
Pages (from-to)	6559-6562
Number of pages	4
Journal	Tetrahedron Letters
Volume	49
Issue number	46
DOIs	https://doi.org/10.1016/j.tetlet.2008.09.012
State	Published - 10 Nov 2008

Keywords

Amines
Amino acids
Asymmetric catalysis
Ferrocenes
Mannich reaction
Organocatalysis

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10.1016/j.tetlet.2008.09.012

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@article{83502513bbad46419d141334f08a0af0,

title = "Enantioselective organocatalytic Mannich reactions of ferrocenecarbaldehyde",

abstract = "The first examples of highly enantioselective organocatalytic Mannich reactions of ferrocenecarbaldehyde are disclosed. The reaction is catalyzed by simple amino acids and gives access to β-arylamino-β-ferrocenylketones in high yields and with up to 99\% ee.",

keywords = "Amines, Amino acids, Asymmetric catalysis, Ferrocenes, Mannich reaction, Organocatalysis",

author = "Guillem Valero and Balaguer, \{Andrea Nekane\} and Albert Moyano and Ramon Rios",

note = "Funding Information: We thank the Spanish Ministry of Science and Education for financial support (Project AYA2006-15648-C02-01), and Professor Josep Mª Rib{\'o} for his interest in this work.",

year = "2008",

month = nov,

day = "10",

doi = "10.1016/j.tetlet.2008.09.012",

language = "British English",

volume = "49",

pages = "6559--6562",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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TY - JOUR

T1 - Enantioselective organocatalytic Mannich reactions of ferrocenecarbaldehyde

AU - Valero, Guillem

AU - Balaguer, Andrea Nekane

AU - Moyano, Albert

AU - Rios, Ramon

N1 - Funding Information: We thank the Spanish Ministry of Science and Education for financial support (Project AYA2006-15648-C02-01), and Professor Josep Mª Ribó for his interest in this work.

PY - 2008/11/10

Y1 - 2008/11/10

N2 - The first examples of highly enantioselective organocatalytic Mannich reactions of ferrocenecarbaldehyde are disclosed. The reaction is catalyzed by simple amino acids and gives access to β-arylamino-β-ferrocenylketones in high yields and with up to 99% ee.

AB - The first examples of highly enantioselective organocatalytic Mannich reactions of ferrocenecarbaldehyde are disclosed. The reaction is catalyzed by simple amino acids and gives access to β-arylamino-β-ferrocenylketones in high yields and with up to 99% ee.

KW - Amines

KW - Amino acids

KW - Asymmetric catalysis

KW - Ferrocenes

KW - Mannich reaction

KW - Organocatalysis

UR - https://www.scopus.com/pages/publications/52949138243

U2 - 10.1016/j.tetlet.2008.09.012

DO - 10.1016/j.tetlet.2008.09.012

M3 - Article

AN - SCOPUS:52949138243

SN - 0040-4039

VL - 49

SP - 6559

EP - 6562

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 46

ER -

Enantioselective organocatalytic Mannich reactions of ferrocenecarbaldehyde

Abstract

Keywords

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