Enantioselective Organocatalytic Cyclopropanation of Enals Using Benzyl Chlorides

Marta Meazza, Maria Ashe, Hun Yi Shin, Hye Sung Yang, Andrea Mazzanti, Jung Woon Yang, Ramon Rios

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Herein, we describe the first enantioselective cyclopropanation of enals using benzyl chlorides as bifunctional (nucleophilic and electrophilic) reagents. The reaction is simply catalyzed by chiral secondary amines to afford the formyl cyclopropane derivatives in good yields with moderate to excellent stereoselectivities.

Original languageBritish English
Pages (from-to)3488-3500
Number of pages13
JournalJournal of Organic Chemistry
Volume81
Issue number9
DOIs
StatePublished - 6 May 2016

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