TY - JOUR
T1 - Emerging Biopolymer-Based Bioadhesives
AU - Li, Jinghang
AU - Yu, Xin
AU - Martinez, Eduardo Enciso
AU - Zhu, Jiaqing
AU - Wang, Ting
AU - Shi, Shengwei
AU - Shin, Su Ryon
AU - Hassan, Shabir
AU - Guo, Chengchen
N1 - Funding Information:
This work was supported by Foundation of Westlake University, National Natural Science Foundation of China (No. 5210030393)
Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2022/2
Y1 - 2022/2
N2 - Bioadhesives have been widely used in healthcare and biomedical applications due to their ease-of-operation for wound closure and repair compared to conventional suturing and stapling. However, several challenges remain for developing ideal bioadhesives, such as unsatisfied mechanical properties, non-tunable biodegradability, and limited biological functions. Considering these concerns, naturally derived biopolymers have been considered good candidates for making bioadhesives owing to their ready availability, facile modification, tunable mechanical properties, and desired biocompatibility and biodegradability. Over the past several years, remarkable progress has been made on biopolymer-based adhesives, covering topics from novel materials designs and advanced processing to clinical translation. The developed bioadhesives have been applied for diverse applications, including tissue adhesion, hemostasis, antimicrobial, wound repair/tissue regeneration, and skin-interfaced bioelectronics. Here in this comprehensive review, recent progress on biopolymer-based bioadhesives is summarized with focuses on clinical translations and multifunctional bioadhesives. Furthermore, challenges and opportunities such as weak adhesion strength at the hydrated state, mechanical mismatch with tissues, and unfavorable immune responses are discussed with an aim to facilitate the future development of high-performance biopolymer-based bioadhesives.
AB - Bioadhesives have been widely used in healthcare and biomedical applications due to their ease-of-operation for wound closure and repair compared to conventional suturing and stapling. However, several challenges remain for developing ideal bioadhesives, such as unsatisfied mechanical properties, non-tunable biodegradability, and limited biological functions. Considering these concerns, naturally derived biopolymers have been considered good candidates for making bioadhesives owing to their ready availability, facile modification, tunable mechanical properties, and desired biocompatibility and biodegradability. Over the past several years, remarkable progress has been made on biopolymer-based adhesives, covering topics from novel materials designs and advanced processing to clinical translation. The developed bioadhesives have been applied for diverse applications, including tissue adhesion, hemostasis, antimicrobial, wound repair/tissue regeneration, and skin-interfaced bioelectronics. Here in this comprehensive review, recent progress on biopolymer-based bioadhesives is summarized with focuses on clinical translations and multifunctional bioadhesives. Furthermore, challenges and opportunities such as weak adhesion strength at the hydrated state, mechanical mismatch with tissues, and unfavorable immune responses are discussed with an aim to facilitate the future development of high-performance biopolymer-based bioadhesives.
KW - bioadhesives
KW - biopolymers
KW - clinical translations
KW - healthcare
UR - http://www.scopus.com/inward/record.url?scp=85121820188&partnerID=8YFLogxK
U2 - 10.1002/mabi.202100340
DO - 10.1002/mabi.202100340
M3 - Review article
C2 - 34957668
AN - SCOPUS:85121820188
SN - 1616-5187
VL - 22
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
IS - 2
M1 - 2100340
ER -