Electrophoretic drug delivery for seizure control

Christopher M. Proctor, Andrea Slézia, Attila Kaszas, Antoine Ghestem, Isabel del Agua, Anna Maria Pappa, Christophe Bernard, Adam Williamson, George G. Malliaras

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

The persistence of intractable neurological disorders necessitates novel therapeutic solutions. We demonstrate the utility of direct in situ electrophoretic drug delivery to treat neurological disorders. We present a neural probe incorporating a microfluidic ion pump (FIP) for on-demand drug delivery and electrodes for recording local neural activity. The FIP works by electrophoretically pumping ions across an ion exchange membrane and thereby delivers only the drug of interest and not the solvent. This “dry” delivery enables precise drug release into the brain region with negligible local pressure increase. The therapeutic potential of the FIP probe is tested in a rodent model of epilepsy. The FIP probe can detect pathological activity and then intervene to stop seizures by delivering inhibitory neurotransmitters directly to the seizure source. We anticipate that further tailored engineering of the FIP platform will enable additional applications in neural interfacing and the treatment of neurological disorders.

Original languageBritish English
Article numbereaau1291
JournalScience Advances
Volume4
Issue number8
DOIs
StatePublished - 29 Aug 2018

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