@article{8d4fc3b180814a668f0f0997fe4770fa,
title = "Electrophoretic drug delivery for seizure control",
abstract = "The persistence of intractable neurological disorders necessitates novel therapeutic solutions. We demonstrate the utility of direct in situ electrophoretic drug delivery to treat neurological disorders. We present a neural probe incorporating a microfluidic ion pump (FIP) for on-demand drug delivery and electrodes for recording local neural activity. The FIP works by electrophoretically pumping ions across an ion exchange membrane and thereby delivers only the drug of interest and not the solvent. This “dry” delivery enables precise drug release into the brain region with negligible local pressure increase. The therapeutic potential of the FIP probe is tested in a rodent model of epilepsy. The FIP probe can detect pathological activity and then intervene to stop seizures by delivering inhibitory neurotransmitters directly to the seizure source. We anticipate that further tailored engineering of the FIP platform will enable additional applications in neural interfacing and the treatment of neurological disorders.",
author = "Proctor, {Christopher M.} and Andrea Sl{\'e}zia and Attila Kaszas and Antoine Ghestem and {del Agua}, Isabel and Pappa, {Anna Maria} and Christophe Bernard and Adam Williamson and Malliaras, {George G.}",
note = "Funding Information: We thank I. Uguz, S. Inal, V. Curto, M. Donahue, M. Ferro, and Z. Magl{\'o}czky for fruitful discussions. A.K. was sponsored by the Marie Curie Intra-European Fellowship for Career Development (no. 625372). C.M.P. acknowledges funding from a Whitaker International Scholar grant administered by the Institute for International Education. A.W. acknowledges funding from the European Research Council under the European Union{\textquoteright}s Horizon 2020 Research and Innovation Programme (grant agreement no. 716867) and from the Excellence Initiative of Aix-Marseille University (A*MIDEX), a French “Investissements d{\textquoteright}Avenir” programme. C.B. acknowledges funding from the A*MIDEX project MIDOE (A_M-AAP-ID-13-24-130531-16.31-BERNARD-HLS). Publisher Copyright: Copyright {\textcopyright} 2018 The Authors.",
year = "2018",
month = aug,
day = "29",
doi = "10.1126/sciadv.aau1291",
language = "British English",
volume = "4",
journal = "Science Advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "8",
}