Electrochemical study of glimepiride and its complexation with β-cyclodextrin

Abd Elgawad M. Radi, Shimaa H. Eissa

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The electrochemical behavior of a hypoglycemic drug, glimepiride (GM), was studied at glassy carbon (GCE) and carbon paste (CPE) electrodes in phosphate buffer over the pH range of 2.7-11.7 using cyclic and differential pulse voltammetry. Oxidation of the drug was shown to be an irreversible and diffusion-controlled process. Using differential pulse voltammetry (DPV), the drug yielded a well-defined voltammetric peak in phosphate buffer pH 6.4 at +1.16 V and pH 7.0 at +1.07 V (vs Ag|AgCl) on glassy carbon and carbon paste electrodes, respectively. This process could be used to determine glimepiride concentrations in the range from 1.0 × 10-5 to 3.2 × 10-5 mol l-1 with a detection limit of 2.0 × 10 -6 mol l-1 in case of the glassy carbon electrode and in the range of 2.0 × 10-6 to 1.5 × 10-5 mol l-1 with a detection limit of 7.5 × 10-7 mol l -1 in case of the carbon paste electrode. The method was successfully applied to the determination of the drug in a tablet dosage form. Next, the formation of an inclusion complex of glimepiride with β-cyclodextrin (β-CD) in phosphate buffer (pH 7.0):methanol (90:10 (v/v)) has been investigated by differential pulse voltammetry as well as UV spectrophotometry and its stability constant was determined by both methods to be 202.0 and 197.9 l mol-1, respectively.

Original languageBritish English
Pages (from-to)13-25
Number of pages13
JournalCollection of Czechoslovak Chemical Communications
Issue number1
StatePublished - 2011


  • Absorption spectroscopy
  • Cyclodextrins
  • Supramolecular chemistry
  • Voltammetry


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