Electrochemical preparation of a reduced graphene oxide/ruthenium oxide modified electrode and its application to the simultaneous determination of serotonin and melatonin

Balamurugan Devadas, Rajesh Madhu, Shen Ming Chen, Vediyappan Veeramani, Muniyandi Rajkumar

    Research output: Contribution to journalArticlepeer-review

    21 Scopus citations

    Abstract

    Herein, we report the simultaneous voltammetric determination of serotonin (5-HT) and melatonin (MET) using a reduced graphene oxide/ruthenium oxide (RGO/RuO2) modified glassy carbon electrode (GCE) for the first time. The as-synthesized RGO/RuO2 composites were characterized by using a variety of techniques, such as scanning electron microscopy (SEM), infrared spectroscopy (IR), X-ray diffraction (XRD), Raman spectroscopy and energy dispersive X-ray spectroscopy (EDX). An enhanced voltammetric oxidation peak was observed for serotonin (5-HT) and melatonin (MET) at RGO/RuO2 modified GCE. Notably, a sufficient voltammetric peak to peak separation (δEp) of 290 mV was found between the two species by using differential pulse voltammetry (DPV) analysis. The lower limit of detection (LOD) was calculated as 0.02 μM for 5-HT and 0.18 μM for MET. Moreover, the fabricated sensor was found to exhibit excellent sensitivity, reliability, and durability, surpassing those achievable with other modified electrodes, which may find use in practical industrial applications.

    Original languageBritish English
    Pages (from-to)654-662
    Number of pages9
    JournalScience of Advanced Materials
    Volume7
    Issue number4
    DOIs
    StatePublished - 2015

    Keywords

    • Melatonin
    • Reduced graphene oxide
    • Ruthenium oxide and simultaneous determination
    • Serotonin

    Fingerprint

    Dive into the research topics of 'Electrochemical preparation of a reduced graphene oxide/ruthenium oxide modified electrode and its application to the simultaneous determination of serotonin and melatonin'. Together they form a unique fingerprint.

    Cite this