Electrochemical determination of isoniazid at electrochemically reduced graphene oxide modified electrode

Srikanth Cheemalapati, Selvakumar Palanisamy, Shen Ming Chen

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    49 Scopus citations

    Abstract

    The electrochemical determination of Isoniazid (INZ) was reported based on the electrochemically reduced graphene oxide (ERGO) modified glassy carbon electrode (GCE). ERGO was prepared by electrochemical reduction of graphene oxide (GO) in the pH 5.0 solution. As prepared ERGO was characterized by Scanning electron microscopy and electrochemical impedance spectroscopy. Linear sweep voltammetry was employed for the electrochemical determination of INZ. ERGO modified GCE has superior electrocatalytic activity towards INZ than GO and Bare GCE electrodes. Moreover, the linear range for INZ has been found from 2 μM to 70 μM with a LOD of 0.17 μM. Furthermore, the sensitivity of the proposed electrode towards INZ was found as 3.987 μA μM-1cm-2. Additionally, ERGO/GCE modified electrode has exhibits good reproducibility, repeatability with storage stability.

    Original languageBritish English
    Pages (from-to)3953-3962
    Number of pages10
    JournalInternational Journal of Electrochemical Science
    Volume8
    Issue number3
    StatePublished - Mar 2013

    Keywords

    • Electrocatalytic activity
    • Electrochemically Reduced Graphene Oxide
    • Glassy carbon electrode
    • Isoniazid
    • Modified electrodes
    • Pharmaceutical applications

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