Efficient trifluoromethylation of C(sp2)-H functionalized α-oxoketene dithioacetals: a route to the regioselective synthesis of functionalized trifluoromethylated pyrazoles

N. Sharma, N. Kumari, T. S. Chundawat, S. Kumar, S. Bhagat

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    7 Scopus citations

    Abstract

    An operationally simple approach for the regioselective construction of diversely substituted trifluoromethylated pyrazoles via nucleophilic trifluoromethylation of iodo-substituted α-oxoketene dithioacetals is described. X-ray crystallographic studies confirmed the trifluoromethylation as well as formation of a regioselective cyclized product. Furthermore, trifluoromethylated pyrazoles bearing thiomethyl groups may allow further functionalization and are of considerable interest in medicinal chemistry.

    Original languageBritish English
    Pages (from-to)10150-10153
    Number of pages4
    JournalRSC Advances
    Volume7
    Issue number17
    DOIs
    StatePublished - 2017

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