Effects of permethrin on biomarkers in Mediterranean clams (Ruditapes decussatus)

B. Sellami; A. Khazri; H. Louati; F. Boufahja; M. Dellali; D. Sheehan; P. Aissa; M. Ridha Driss; E. Mahmoudi; H. Beyrem

doi:10.1007/s00128-014-1225-6

Effects of permethrin on biomarkers in Mediterranean clams (Ruditapes decussatus)

B. Sellami, A. Khazri, H. Louati, F. Boufahja, M. Dellali, D. Sheehan, P. Aissa, M. Ridha Driss, E. Mahmoudi, H. Beyrem

Chemistry

Faculté des Sciences de Bizerte

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The present study was focused on the assessment of Catalase (CAT) and Acetylcholinesterase (AChE) activities in Mediterranean clams (Ruditapes decussatus) exposed to 50, 100 and 150 μg/L of Permethrin for 5, 10, 15, 20 and 25 days. In water, the measured concentrations of Permethrin in the treated aquariums were respectively 16.66, 38.24 and 55.61 μg/L. Results showed that CAT activity was increased after 5 days of exposure to high concentration reaching maximum value of 10.14 μmol/min/mg proteins after 25 days. However, no significant changes in AChE activity after 5 days of exposure were detected in all treated groups. AChE activity was significantly inhibited after 10 days with 100 and 150 μg/L and still depending on concentration and time. Maximum inhibition of AChE activity was reached after 25 days with the highest concentration of Permethrin. Our data indicated that exposure to Permethrin modifies biomarker profiles inducing oxidative stress and reducing AChE activity in Mediterranean clams.

Original language	British English
Pages (from-to)	574-578
Number of pages	5
Journal	Bulletin of Environmental Contamination and Toxicology
Volume	92
Issue number	5
DOIs	https://doi.org/10.1007/s00128-014-1225-6
State	Published - May 2014

Keywords

Mediterranean clam
Neurotoxicity
Oxidative stress
Permethrin
Ruditapes decussatus

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10.1007/s00128-014-1225-6

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title = "Effects of permethrin on biomarkers in Mediterranean clams (Ruditapes decussatus)",

abstract = "The present study was focused on the assessment of Catalase (CAT) and Acetylcholinesterase (AChE) activities in Mediterranean clams (Ruditapes decussatus) exposed to 50, 100 and 150 μg/L of Permethrin for 5, 10, 15, 20 and 25 days. In water, the measured concentrations of Permethrin in the treated aquariums were respectively 16.66, 38.24 and 55.61 μg/L. Results showed that CAT activity was increased after 5 days of exposure to high concentration reaching maximum value of 10.14 μmol/min/mg proteins after 25 days. However, no significant changes in AChE activity after 5 days of exposure were detected in all treated groups. AChE activity was significantly inhibited after 10 days with 100 and 150 μg/L and still depending on concentration and time. Maximum inhibition of AChE activity was reached after 25 days with the highest concentration of Permethrin. Our data indicated that exposure to Permethrin modifies biomarker profiles inducing oxidative stress and reducing AChE activity in Mediterranean clams.",

keywords = "Mediterranean clam, Neurotoxicity, Oxidative stress, Permethrin, Ruditapes decussatus",

author = "B. Sellami and A. Khazri and H. Louati and F. Boufahja and M. Dellali and D. Sheehan and P. Aissa and Driss, {M. Ridha} and E. Mahmoudi and H. Beyrem",

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AU - Sellami, B.

AU - Khazri, A.

AU - Louati, H.

AU - Boufahja, F.

AU - Dellali, M.

AU - Sheehan, D.

AU - Aissa, P.

AU - Driss, M. Ridha

AU - Mahmoudi, E.

AU - Beyrem, H.

PY - 2014/5

Y1 - 2014/5

N2 - The present study was focused on the assessment of Catalase (CAT) and Acetylcholinesterase (AChE) activities in Mediterranean clams (Ruditapes decussatus) exposed to 50, 100 and 150 μg/L of Permethrin for 5, 10, 15, 20 and 25 days. In water, the measured concentrations of Permethrin in the treated aquariums were respectively 16.66, 38.24 and 55.61 μg/L. Results showed that CAT activity was increased after 5 days of exposure to high concentration reaching maximum value of 10.14 μmol/min/mg proteins after 25 days. However, no significant changes in AChE activity after 5 days of exposure were detected in all treated groups. AChE activity was significantly inhibited after 10 days with 100 and 150 μg/L and still depending on concentration and time. Maximum inhibition of AChE activity was reached after 25 days with the highest concentration of Permethrin. Our data indicated that exposure to Permethrin modifies biomarker profiles inducing oxidative stress and reducing AChE activity in Mediterranean clams.

AB - The present study was focused on the assessment of Catalase (CAT) and Acetylcholinesterase (AChE) activities in Mediterranean clams (Ruditapes decussatus) exposed to 50, 100 and 150 μg/L of Permethrin for 5, 10, 15, 20 and 25 days. In water, the measured concentrations of Permethrin in the treated aquariums were respectively 16.66, 38.24 and 55.61 μg/L. Results showed that CAT activity was increased after 5 days of exposure to high concentration reaching maximum value of 10.14 μmol/min/mg proteins after 25 days. However, no significant changes in AChE activity after 5 days of exposure were detected in all treated groups. AChE activity was significantly inhibited after 10 days with 100 and 150 μg/L and still depending on concentration and time. Maximum inhibition of AChE activity was reached after 25 days with the highest concentration of Permethrin. Our data indicated that exposure to Permethrin modifies biomarker profiles inducing oxidative stress and reducing AChE activity in Mediterranean clams.

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KW - Oxidative stress

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KW - Ruditapes decussatus

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Effects of permethrin on biomarkers in Mediterranean clams (Ruditapes decussatus)

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