Effects of long-term ovariectomy and ovarian steroids on somatogenic binding sites in rat brain and liver

Amged Mustafa, Nenad Bogdanovic, Fred Nyberg, Isam Suliman, Atiqul Islam, Paul Roos, Bengt Winblad, Abdu Adem

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The effects of long-term ovariectomy and replacement with ovarian steroids on the levels of brain and liver somatogenic binding sites as well as plasma and liver growth hormone (GH) were studied in sham-operated (Sham) and ovariectomized female rats receiving either, 17β-estradiol (OVX-E), progesterone (OVX-P), or vehicle (OVX). Long-term ovariectomy decreased the levels of somatogenic binding sites in the choroid plexus and liver as well as GH in plasma and liver. The levels of these sites in the choroid plexus were partially restored only by estradiol replacement. Moreover, exogenous estradiol but not progesterone restored the levels of plasma and liver GH as well as liver somatogenic binding sites. Our results suggest that estrogens regulate the levels of somatogenic binding sites in the liver and choroid plexus.

Original languageBritish English
Pages (from-to)193-196
Number of pages4
JournalNeuroscience Letters
Volume194
Issue number3
DOIs
StatePublished - 21 Jul 1995

Keywords

  • Growth hormone
  • Long-term ovariectomy
  • Ovarian steroids
  • Rat brain
  • Receptor autoradiography
  • Somatogenic binding sites

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