Effects of combined treatment of probiotics and metformin in management of type 2 diabetes: A systematic review and meta-analysis

Hamda Memon, Fatima Abdulla, Tea Reljic, Saif Alnuaimi, Fadila Serdarevic, Zelija Velija Asimi, Ambuj Kumar, Sabina Semiz

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Background: Lifestyle changes and dietary intervention, including the use of probiotics, can modulate dysbiosis of gut microbiome and contribute to the management of type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis aim to assess the efficacy of metformin plus probiotics versus metformin alone on outcomes in patients with T2DM. Methods: We searched MEDLINE and EMBASE from inception to February 2023 to identify all randomized controlled trials (RCTs), which compared the use of metformin plus probiotics versus metformin alone in adult patients with T2DM. Data were summarized as mean differences (MD) with 95 % confidence interval (CI) and pooled under the random effects model. Findings: Fourteen RCTs (17 comparisons, 1009 patients) were included in this systematic review. Pooled results show a significant decrease in fasting glucose (FG) (MD = −0.64, 95 % CI = −1.06, −0.22) and HbA1c (MD = −0.29, 95 % CI = −0.47, −0.10) levels in patients with T2DM treated with metformin plus probiotics versus metformin alone. The addition of probiotics to metformin resulted in lower odds of gastrointestinal adverse events (Odds ratio = 0.18, 95 % CI = 0.09, 0.3.8; I2 = 0 %). Conclusions: The addition of probiotics to metformin therapy is associated with improvement in T2DM outcomes. However, high-quality and adequately reported RCTs are needed in the future to confirm our findings.

Original languageBritish English
Article number110806
JournalDiabetes Research and Clinical Practice
Volume202
DOIs
StatePublished - Aug 2023

Keywords

  • Fasting glucose
  • Fasting insulin
  • Gastrointestinal intolerance
  • HbA1c
  • Insulin resistance
  • Lipids
  • Metformin
  • Probiotic

Fingerprint

Dive into the research topics of 'Effects of combined treatment of probiotics and metformin in management of type 2 diabetes: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this