TY - JOUR
T1 - Effect of replacement of mandibular defects with a modular endoprosthesis on bone mineral density in a monkey model
AU - Wong, R. C.W.
AU - Lee, S.
AU - Tideman, H.
AU - Merkx, M. A.W.
AU - Jansen, J.
AU - Liao, K.
N1 - Funding Information:
SingHealth Foundation grant SHF/SP001/2007.
PY - 2011/6
Y1 - 2011/6
N2 - The effect of mandibular modular endoprostheses on bone mineral density (BMD) in the stem regions was studied. Modular endoprostheses were inserted into standardized mandibular condyle or body defects in 16 Macaca fascicularis. Each group of eight monkeys was divided into two groups, one killed at 3 months, the other at 6 months post-surgery. The mandibles were harvested, sectioned and scanned with a micro-computed tomography scanner. The reconstructed slices, made at a right angles to the long axis of the prosthesis, were analysed using software to calculate BMD in regions of interest buccal, lingual and inferior to the stems of the endoprosthesis. Measurements of the contralateral sides of three monkeys that underwent a similar procedure were used as control/baseline BMD. BMD for the condyle replacement group did not differ significantly from the control group. At 6 months, BMD decreased slightly; significant only at the inferior region. BMD for the body replacement group was significantly lower in all regions compared with control and condyle replacement groups probably because of connection screw loosening and infection. Loss of BMD in the peri-implant region of a modular endoprosthesis for mandibular replacement is minimal up to 6 months postoperatively, provided the device remains stable and well-fixed.
AB - The effect of mandibular modular endoprostheses on bone mineral density (BMD) in the stem regions was studied. Modular endoprostheses were inserted into standardized mandibular condyle or body defects in 16 Macaca fascicularis. Each group of eight monkeys was divided into two groups, one killed at 3 months, the other at 6 months post-surgery. The mandibles were harvested, sectioned and scanned with a micro-computed tomography scanner. The reconstructed slices, made at a right angles to the long axis of the prosthesis, were analysed using software to calculate BMD in regions of interest buccal, lingual and inferior to the stems of the endoprosthesis. Measurements of the contralateral sides of three monkeys that underwent a similar procedure were used as control/baseline BMD. BMD for the condyle replacement group did not differ significantly from the control group. At 6 months, BMD decreased slightly; significant only at the inferior region. BMD for the body replacement group was significantly lower in all regions compared with control and condyle replacement groups probably because of connection screw loosening and infection. Loss of BMD in the peri-implant region of a modular endoprosthesis for mandibular replacement is minimal up to 6 months postoperatively, provided the device remains stable and well-fixed.
KW - bone mineral density
KW - mandibular reconstruction
KW - modular endoprosthesis
UR - http://www.scopus.com/inward/record.url?scp=79956268024&partnerID=8YFLogxK
U2 - 10.1016/j.ijom.2010.10.028
DO - 10.1016/j.ijom.2010.10.028
M3 - Article
C2 - 21216566
AN - SCOPUS:79956268024
SN - 0901-5027
VL - 40
SP - 633
EP - 639
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
IS - 6
ER -