Effect of gender and diabetes on major depressive disorder using heart rate asymmetry

Chandan K. Karmakar, Herbert F. Jelinek, Paul Warner, Ahsan H. Khandoker, Marimuthu Palaniswami

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations

Abstract

In this study, we have investigated how heart rate asymmetry (HRA) changes in major depressive disorder (MDD) subjects with comorbid diabetes as well as in male and female. Depression score was determined based on PHQ-9 questionnaire and from 135 subjects 70 subjects were selected with 1000 or more RR intervals. Heart rate asymmetry is a Poincaré plot based nonlinear technique to analyze the asymmetry using RR interval time-series signal. Three commonly used HRA indices Guzik's index (GI), Porta's index (PI) and Ehlers' index (EI) were used to understand the changes in HRA in MDD. Results indicate significantly (p<0.05) different GI and EI values between 'Dep' and 'NonDep' subgroups in 'Combined' group. All three HRA indices are found significantly different in presence of depression in female subjects. These results provide better understanding about changes in HRA in MDD and HRA indices could be a plausible nonlinear HRV feature for differentiating Depression 'Dep' from NonDepression 'NonDep' group - i) without comorbid diabetes; ii) in Female subjects.

Original languageBritish English
Title of host publication2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages6679-6682
Number of pages4
ISBN (Electronic)9781424479290
DOIs
StatePublished - 2 Nov 2014
Event2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014 - Chicago, United States
Duration: 26 Aug 201430 Aug 2014

Publication series

Name2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014

Conference

Conference2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014
Country/TerritoryUnited States
CityChicago
Period26/08/1430/08/14

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