@inproceedings{9a7187bcf4bf435cbdcaa936aff9beed,
title = "Effect of β-blocker on maternal-fetal heart rates and coupling in pregnant mice and fetuses",
abstract = "The aim of this preliminary study is to look how maternal-fetal heart rates and their coupling patterns are influenced by injection of β blocker(propranolol) into pregnant mice. Total of 6 pregnant female mice were divided into two groups [control (N=3) and β blockade (N=3)]. On 17.5-day mean heart rate of mothers and fetuses (MHR and FHR) were simultaneously measured for 20 minutes (10 minutes under normal condition and 10 minutes with saline (to control group) and propranolol (to the β blockade group) solution by using an invasive maternal and fetal electrocardiogram techniques with needle electrodes. Results show that FHR decreased and maternal-fetal heart rate coupling (λ) patterns changed with propranolol infusion (no change with saline). Statistical test showed that changes (increase/decrease from pre to post values) in mean, rmssd and power spectral density (PSD) (2~4 Hz)) of MHR, short term variability of FHR, PSD (0.0~1.0 Hz) of FHR and λ were found to be significantly associated with treatment types (saline to propranolol). The presented results and protocol allow for assessment of β adrenergic control of maternal and fetal heart, which will further enhance the value of the mouse as a model of heritable human pregnancy and hypertension.",
author = "Khandoker, {Ahsan H.} and Chihiro Yoshida and Yoshiyuki Kasahara and Kiyoe Funamoto and Kana Nakanishi and Miyabi Fukase and Keiichi Kanda and Kyuichi Niizeki and Yoshitaka Kimura",
note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019 ; Conference date: 23-07-2019 Through 27-07-2019",
year = "2019",
month = jul,
doi = "10.1109/EMBC.2019.8856719",
language = "British English",
series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "1784--1787",
booktitle = "2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2019",
address = "United States",
}