@article{0ad747ca1c0f4938b93b13fba1a379f3,
title = "Dynamics of a gel-based artificial tear film with an emphasis on dry disease treatment applications",
abstract = "This paper discusses the spreading of gel-based ophthalmic formulation on the cornea surface assumed to be flat. We show that gel-based formulations exhibit rheological behaviors that the Herschel–Bulkley model can describe. The continuity and momentum equations are solved numerically using the monofluid formulation and the volume-of-fluid (VOF) method. We investigated the influence of the rheological properties, namely the consistency, the yield stress, and the flow behavior index, on the spreading of a gel-based artificial tear over the cornea surface. We propose optimal values of these properties for efficient gel-based artificial tears.",
keywords = "Dry eye disease, Gel-based artificial tears, Herschel–Bulkley model, Tear film breakup, VOF method",
author = "Hamza Mehdaoui and Abderrahmane, {Hamid Ait} and {de Loubens}, Clement and Bouda, {Fa{\"i}{\c c}al Nait} and Sofiane Hamani",
note = "Funding Information: Funding: Ministry of Higher Education and Scientific Research of Algeria. LRP is part of the LabEx Tec 21 (Investissements d{\textquoteright}Avenir–grant agreement ANR-11-LABX-0030) and Institut Carnot PolyNat (Investissements d{\textquoteright}Avenir–grant agreement ANR-11-CARN-030-01). Funding Information: Ministry of Higher Education and Scientific Research of Algeria. LRP is part of the LabEx Tec 21 (Investissements d{\textquoteright}Avenir–grant agreement ANR-11-LABX-0030) and Institut Carnot PolyNat (Investissements d{\textquoteright}Avenir–grant agreement ANR-11-CARN-030-01). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = dec,
doi = "10.3390/gels7040215",
language = "British English",
volume = "7",
journal = "Gels",
issn = "2310-2861",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",
}