Drug interactions with statins

Anida Causevic-Ramosevac, Sabina Semiz

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are generally well tolerated as monotherapy. Statins are associated with two important adverse effects, asymptomatic elevation in liver enzymes and myopathy. Myopathy is most likely to occur when statins are administered with other drugs. Statins are substrates of multiple drug transporters (including OAT- -P1B1, BCRP and MDR1) and several cytochrome P450 (CYP) enzymes (including CYP3A4, CYP2C8, CYP2C19, and CYP2C9). Possible adverse effects of statins can occur due to interactions in concomitant use of drugs that substantially inhibit or induce their methabolic pathway. This review summarizes the most important interactions of statins.

Original languageBritish English
Pages (from-to)277-293
Number of pages17
JournalActa Pharmaceutica
Volume63
Issue number3
DOIs
StatePublished - 1 Sep 2013

Keywords

  • adverse effects
  • cytochrome P450 (CYP) enzymes
  • drug interactions
  • drug transporters
  • statins

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