Dose calculation from a D-D-reaction-based BSA for boron neutron capture synovectomy

Khalid Abdalla; A. A. Naqvi; N. Maalej; B. Elshahat

doi:10.1016/j.apradiso.2009.09.041

Dose calculation from a D-D-reaction-based BSA for boron neutron capture synovectomy

Khalid Abdalla, A. A. Naqvi, N. Maalej, B. Elshahat

Physics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Monte Carlo simulations were carried out to calculate dose in a knee phantom from a D-D-reaction-based Beam Shaping Assembly (BSA) for Boron Neutron Capture Synovectomy (BNCS). The BSA consists of a D(d,n)-reaction-based neutron source enclosed inside a polyethylene moderator and graphite reflector. The polyethylene moderator and graphite reflector sizes were optimized to deliver the highest ratio of thermal to fast neutron yield at the knee phantom. Then neutron dose was calculated at various depths in a knee phantom loaded with boron and therapeutic ratios of synovium dose/skin dose and synovium dose/bone dose were determined. Normalized to same boron loading in synovium, the values of the therapeutic ratios obtained in the present study are 12-30 times higher than the published values.

Original language	British English
Pages (from-to)	751-754
Number of pages	4
Journal	Applied Radiation and Isotopes
Volume	68
Issue number	4-5
DOIs	https://doi.org/10.1016/j.apradiso.2009.09.041
State	Published - Apr 2010

Keywords

Accelerator
BNCS
D(d
Knee phantom
n) reaction
Polyethylene moderator

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10.1016/j.apradiso.2009.09.041

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title = "Dose calculation from a D-D-reaction-based BSA for boron neutron capture synovectomy",

abstract = "Monte Carlo simulations were carried out to calculate dose in a knee phantom from a D-D-reaction-based Beam Shaping Assembly (BSA) for Boron Neutron Capture Synovectomy (BNCS). The BSA consists of a D(d,n)-reaction-based neutron source enclosed inside a polyethylene moderator and graphite reflector. The polyethylene moderator and graphite reflector sizes were optimized to deliver the highest ratio of thermal to fast neutron yield at the knee phantom. Then neutron dose was calculated at various depths in a knee phantom loaded with boron and therapeutic ratios of synovium dose/skin dose and synovium dose/bone dose were determined. Normalized to same boron loading in synovium, the values of the therapeutic ratios obtained in the present study are 12-30 times higher than the published values.",

keywords = "Accelerator, BNCS, D(d, Knee phantom, n) reaction, Polyethylene moderator",

author = "Khalid Abdalla and Naqvi, {A. A.} and N. Maalej and B. Elshahat",

note = "Funding Information: The authors wish to acknowledge the support of the Physics Department at King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia. ",

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AU - Abdalla, Khalid

AU - Naqvi, A. A.

AU - Maalej, N.

AU - Elshahat, B.

N1 - Funding Information: The authors wish to acknowledge the support of the Physics Department at King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia.

PY - 2010/4

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AB - Monte Carlo simulations were carried out to calculate dose in a knee phantom from a D-D-reaction-based Beam Shaping Assembly (BSA) for Boron Neutron Capture Synovectomy (BNCS). The BSA consists of a D(d,n)-reaction-based neutron source enclosed inside a polyethylene moderator and graphite reflector. The polyethylene moderator and graphite reflector sizes were optimized to deliver the highest ratio of thermal to fast neutron yield at the knee phantom. Then neutron dose was calculated at various depths in a knee phantom loaded with boron and therapeutic ratios of synovium dose/skin dose and synovium dose/bone dose were determined. Normalized to same boron loading in synovium, the values of the therapeutic ratios obtained in the present study are 12-30 times higher than the published values.

KW - Accelerator

KW - BNCS

KW - D(d

KW - Knee phantom

KW - n) reaction

KW - Polyethylene moderator

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ER -

Dose calculation from a D-D-reaction-based BSA for boron neutron capture synovectomy

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Keywords

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