Differential expression of the estrogen receptor-related receptor γ in the mouse brain

To elucidate estrogen functions, the expression of the estrogen receptor-related receptor ERRγ, a novel orphan nuclear receptor regulating transcription via estrogen responsive elements, has been localized by in situ hybridization in adult murine brain. ERRγ transcripts were abundantly present in the isocortex, the olfactory system, cranial nerve nuclei and major parts of the coordination centers, e.g. reticular formation and major parts of the extrapyramidal motor systems. In addition, ERRγ expression was detected in trigeminal ganglion neurons. ERRγ distribution was clearly distinguished from that described for ERRα, for ERRβ, and for estrogen receptors (ER) pointing at functional differences between ERRγ and these receptors. (C) 2000 Elsevier Science B.V.