Dielectrophoretic response of DNA shows different conduction mechanisms for poly(dG)-poly(dC) and poly(dA)-poly(dT) in solution

A. S. Mohamad; J. C.G. Jeynes; M. P. Hughes

doi:10.1109/TNB.2014.2299215

Dielectrophoretic response of DNA shows different conduction mechanisms for poly(dG)-poly(dC) and poly(dA)-poly(dT) in solution

A. S. Mohamad, J. C.G. Jeynes, M. P. Hughes

Biomedical Engineering & Biotechnology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Although the subject of some scrutiny over the years, the mechanism of conduction in DNA has not yet been resolved, with competing theories suggesting either electronic and ionic conduction mechanisms. In this paper we use dielectrophoresis to determine the electrical properties of poly(dG)-poly(dC) (GC) and poly(dA)-poly(dT) (AT) DNA in solution. The molecules show different conduction mechanisms; GC DNA exhibits conduction primarily through the molecule, whereas in AT DNA conduction through the counterion cloud surrounding the molecule in solution is more significant.

Original language	British English
Article number	6750134
Pages (from-to)	51-54
Number of pages	4
Journal	IEEE Transactions on Nanobioscience
Volume	13
Issue number	1
DOIs	https://doi.org/10.1109/TNB.2014.2299215
State	Published - Mar 2014

Keywords

Bioelectric phenomena
dielectrophoresis
DNA
electrokinetic
molecular biophysics

Access to Document

10.1109/TNB.2014.2299215

Cite this

@article{1ae175dd3c5d46e180bc73112e3781e0,

title = "Dielectrophoretic response of DNA shows different conduction mechanisms for poly(dG)-poly(dC) and poly(dA)-poly(dT) in solution",

abstract = "Although the subject of some scrutiny over the years, the mechanism of conduction in DNA has not yet been resolved, with competing theories suggesting either electronic and ionic conduction mechanisms. In this paper we use dielectrophoresis to determine the electrical properties of poly(dG)-poly(dC) (GC) and poly(dA)-poly(dT) (AT) DNA in solution. The molecules show different conduction mechanisms; GC DNA exhibits conduction primarily through the molecule, whereas in AT DNA conduction through the counterion cloud surrounding the molecule in solution is more significant.",

keywords = "Bioelectric phenomena, dielectrophoresis, DNA, electrokinetic, molecular biophysics",

author = "Mohamad, {A. S.} and Jeynes, {J. C.G.} and Hughes, {M. P.}",

year = "2014",

month = mar,

doi = "10.1109/TNB.2014.2299215",

language = "British English",

volume = "13",

pages = "51--54",

journal = "IEEE Transactions on Nanobioscience",

issn = "1536-1241",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "1",

}

TY - JOUR

T1 - Dielectrophoretic response of DNA shows different conduction mechanisms for poly(dG)-poly(dC) and poly(dA)-poly(dT) in solution

AU - Mohamad, A. S.

AU - Jeynes, J. C.G.

AU - Hughes, M. P.

PY - 2014/3

Y1 - 2014/3

N2 - Although the subject of some scrutiny over the years, the mechanism of conduction in DNA has not yet been resolved, with competing theories suggesting either electronic and ionic conduction mechanisms. In this paper we use dielectrophoresis to determine the electrical properties of poly(dG)-poly(dC) (GC) and poly(dA)-poly(dT) (AT) DNA in solution. The molecules show different conduction mechanisms; GC DNA exhibits conduction primarily through the molecule, whereas in AT DNA conduction through the counterion cloud surrounding the molecule in solution is more significant.

AB - Although the subject of some scrutiny over the years, the mechanism of conduction in DNA has not yet been resolved, with competing theories suggesting either electronic and ionic conduction mechanisms. In this paper we use dielectrophoresis to determine the electrical properties of poly(dG)-poly(dC) (GC) and poly(dA)-poly(dT) (AT) DNA in solution. The molecules show different conduction mechanisms; GC DNA exhibits conduction primarily through the molecule, whereas in AT DNA conduction through the counterion cloud surrounding the molecule in solution is more significant.

KW - Bioelectric phenomena

KW - dielectrophoresis

KW - DNA

KW - electrokinetic

KW - molecular biophysics

UR - http://www.scopus.com/inward/record.url?scp=84896264670&partnerID=8YFLogxK

U2 - 10.1109/TNB.2014.2299215

DO - 10.1109/TNB.2014.2299215

M3 - Article

C2 - 24594514

AN - SCOPUS:84896264670

SN - 1536-1241

VL - 13

SP - 51

EP - 54

JO - IEEE Transactions on Nanobioscience

JF - IEEE Transactions on Nanobioscience

IS - 1

M1 - 6750134

ER -

Dielectrophoretic response of DNA shows different conduction mechanisms for poly(dG)-poly(dC) and poly(dA)-poly(dT) in solution

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this