TY - JOUR
T1 - Development of chitosan/poly (vinyl alcohol)/graphene oxide loaded with vanadium doped titanium dioxide patch for visible light driven antibacterial activity and accelerated wound healing application
AU - Venkataprasanna, K. S.
AU - Prakash, J.
AU - Mathapati, Santosh S.
AU - Bharath, G.
AU - Banat, Fawzi
AU - Venkatasubbu, G. Devanand
N1 - Funding Information:
The authors K.S. Venkataprasanna and Dr. G. Devanand Venkatasubbu thank SRM research Institute for providing HRTEM and Raman facility.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/12/15
Y1 - 2021/12/15
N2 - Wound healing is a multi-stage process that is dynamic, interactive, and complicated. However, many nanomaterials are employed to expedite wound healing by demonstrating antibacterial activity or boosting cell proliferation. But only one phase is focused during the wound healing process. As a result, there is a need for optimum wound dressing materials that promotes different wound healing cascades with ideal properties. Herein, Graphene Oxide loaded with vanadium (V) doped titanium dioxide (TiO2) blended with chitosan, and polyvinyl alcohol (CS/PVA/GO/TiO2-V) patch was developed for wound healing. XRD, FTIR and FE-SEM analyses were carried out to study the morphology and structural property of the patch. The fabricated patch has a high surface porosity, excellent moisture vapor transfer rate, appropriate swelling behaviour, and oxygen permeability, which results in an excellent moist environment for wound breathing and effective management of wound exudates. The antibacterial test showed significant antibacterial efficacy against wound infections in the presence of light when compared to dark. In-vitro analysis such as hemocompatibility, cytotoxicity, cell adhesion, and scratch assay show the predicted potential wound healing application with high biocompatibility. These results suggest that CS/PVA/GO/TiO2-V patch provides a microenvironment favourable to cells' growth and differentiation and positively modulates full-thickness wounds' healing.
AB - Wound healing is a multi-stage process that is dynamic, interactive, and complicated. However, many nanomaterials are employed to expedite wound healing by demonstrating antibacterial activity or boosting cell proliferation. But only one phase is focused during the wound healing process. As a result, there is a need for optimum wound dressing materials that promotes different wound healing cascades with ideal properties. Herein, Graphene Oxide loaded with vanadium (V) doped titanium dioxide (TiO2) blended with chitosan, and polyvinyl alcohol (CS/PVA/GO/TiO2-V) patch was developed for wound healing. XRD, FTIR and FE-SEM analyses were carried out to study the morphology and structural property of the patch. The fabricated patch has a high surface porosity, excellent moisture vapor transfer rate, appropriate swelling behaviour, and oxygen permeability, which results in an excellent moist environment for wound breathing and effective management of wound exudates. The antibacterial test showed significant antibacterial efficacy against wound infections in the presence of light when compared to dark. In-vitro analysis such as hemocompatibility, cytotoxicity, cell adhesion, and scratch assay show the predicted potential wound healing application with high biocompatibility. These results suggest that CS/PVA/GO/TiO2-V patch provides a microenvironment favourable to cells' growth and differentiation and positively modulates full-thickness wounds' healing.
KW - Biocompatibility
KW - Chitosan
KW - Graphene oxide-titanium dioxide
KW - Photocatalytic
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=85119006776&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2021.10.207
DO - 10.1016/j.ijbiomac.2021.10.207
M3 - Article
C2 - 34742841
AN - SCOPUS:85119006776
SN - 0141-8130
VL - 193
SP - 1430
EP - 1448
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -