Current applications of different type of aqueous two-phase systems

Yee Koon Yau, Chien Wei Ooi, Eng Poh Ng, John Chi Wei Lan, Tau Chuan Ling, Pau Loke Show

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations


In recent year, aqueous two-phase system (ATPS) has become a proven tool used in separation and purification technology. The application of ATPSs in clarification, partitioning and partial purification of biomolecules and bioproducts had showed the rapid development. This method is able to give high recovery yield and high purity in a single step. The ATPS shows characteristics of high selectivity and is easily to scale up. Therefore, ATPS offers an attractive alternative that meets the requirements of the high demand in industry processes and it is also beneficial in terms of economic and environmental protection. In the past, a lot of works and researches have been done in order to develop feasible separation processes using different types of ATPSs and their applications in numerous product separations. This paper aims to review on the recent literature works in the development of different type of ATPSs and their applications in novel separations and purifications of biomaterials.

Original languageBritish English
Article number49
JournalBioresources and Bioprocessing
Issue number1
StatePublished - 1 Dec 2015


  • Aqueous two-phase system
  • Bioproducts recovery
  • Partitioning
  • Purification
  • Recovery yield


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