Cu(II)-catalyzed tandem synthesis of 2-imino[1,3]benzothiazines from 2-aminoaryl acrylates via thioamidation and concomitant chemoselective thia-Michael addition

Rakesh K. Saunthwal, Monika Patel, Sushil Kumar, Akhilesh K. Verma

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    25 Scopus citations

    Abstract

    An efficient copper-catalyzed tandem approach for the synthesis of 2-imino[1,3]benzothiazines by the reaction of easily accessible 2-aminoaryl acrylates with isothiocyanates via in situ thioamidation and concomitant chemoselective intramolecular thia-Michael addition is described. Intramolecular cyclization was selectively triggered by the nitrogen 'b' of the thiourea intermediate P.

    Original languageBritish English
    Pages (from-to)677-681
    Number of pages5
    JournalTetrahedron Letters
    Volume56
    Issue number5
    DOIs
    StatePublished - 28 Jan 2015

    Keywords

    • Alkene
    • Aminoaryl acrylates
    • Chemoselective
    • Copper-catalyzed
    • Thia-Michael addition

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