Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal: In vivo imaging

Sungwan Kim; Gyeongwon Yun; Suman Khan; Jinhwan Kim; James Murray; Yeong Mi Lee; Won Jong Kim; Gyudong Lee; Sungjee Kim; Dinesh Shetty; Joo Hyun Kang; Jung Young Kim; Kyeng Min Park; Kimoon Kim

doi:10.1039/c7mh00038c

Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal: In vivo imaging

Sungwan Kim
, Gyeongwon Yun
, Suman Khan
, Jinhwan Kim
, James Murray
, Yeong Mi Lee
, Won Jong Kim
, Gyudong Lee
, Sungjee Kim
, Dinesh Shetty
, Joo Hyun Kang
, Jung Young Kim
, Kyeng Min Park
, Kimoon Kim

Chemistry

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.

Original language	British English
Pages (from-to)	450-455
Number of pages	6
Journal	Materials Horizons
Volume	4
Issue number	3
DOIs	https://doi.org/10.1039/c7mh00038c
State	Published - 2017

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10.1039/c7mh00038c

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title = "Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal: In vivo imaging",

abstract = "Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.",

author = "Sungwan Kim and Gyeongwon Yun and Suman Khan and Jinhwan Kim and James Murray and Lee, \{Yeong Mi\} and Kim, \{Won Jong\} and Gyudong Lee and Sungjee Kim and Dinesh Shetty and Kang, \{Joo Hyun\} and Kim, \{Jung Young\} and Park, \{Kyeng Min\} and Kimoon Kim",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7mh00038c",

language = "British English",

volume = "4",

pages = "450--455",

journal = "Materials Horizons",

issn = "2051-6347",

publisher = "Royal Society of Chemistry",

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}

TY - JOUR

T1 - Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal

T2 - In vivo imaging

AU - Kim, Sungwan

AU - Yun, Gyeongwon

AU - Khan, Suman

AU - Kim, Jinhwan

AU - Murray, James

AU - Lee, Yeong Mi

AU - Kim, Won Jong

AU - Lee, Gyudong

AU - Kim, Sungjee

AU - Shetty, Dinesh

AU - Kang, Joo Hyun

AU - Kim, Jung Young

AU - Park, Kyeng Min

AU - Kim, Kimoon

PY - 2017

Y1 - 2017

N2 - Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.

AB - Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.

UR - https://www.scopus.com/pages/publications/85021815345

U2 - 10.1039/c7mh00038c

DO - 10.1039/c7mh00038c

M3 - Article

AN - SCOPUS:85021815345

SN - 2051-6347

VL - 4

SP - 450

EP - 455

JO - Materials Horizons

JF - Materials Horizons

IS - 3

ER -

Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal: In vivo imaging

Abstract

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