Abstract
Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.
Original language | British English |
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Pages (from-to) | 450-455 |
Number of pages | 6 |
Journal | Materials Horizons |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - 2017 |