Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal: In vivo imaging

Sungwan Kim, Gyeongwon Yun, Suman Khan, Jinhwan Kim, James Murray, Yeong Mi Lee, Won Jong Kim, Gyudong Lee, Sungjee Kim, Dinesh Shetty, Joo Hyun Kang, Jung Young Kim, Kyeng Min Park, Kimoon Kim

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Cucurbit[6]uril (CB[6])-based polymer nanocapsules (CB[6]PNs) were used as a multimodal platform for cancer-targeted in vivo bioimaging. By taking advantage of the strong and robust host-guest interaction between CB[6] and spermidine (spmd) under in vivo conditions, the surface of the CB[6]PNs was non-covalently modified with various spmd-conjugated functionalities in a modular manner. The CB[6]PNs modified with imaging probes and targeting ligands showed tumor targeted PET and NIR imaging in mice. This proof of concept demonstrates the potential of non-covalently modified nanomaterials in real world in vivo systems.

Original languageBritish English
Pages (from-to)450-455
Number of pages6
JournalMaterials Horizons
Volume4
Issue number3
DOIs
StatePublished - 2017

Fingerprint

Dive into the research topics of 'Cucurbit[6]uril-based polymer nanocapsules as a non-covalent and modular bioimaging platform for multimodal: In vivo imaging'. Together they form a unique fingerprint.

Cite this