TY - JOUR
T1 - Controlled Synthesis of Dendrite-like Polyglycerols Using Aluminum Complex for Biomedical Applications
AU - Perumal, Govindaraj
AU - Pappuru, Sreenath
AU - Doble, Mukesh
AU - Chakraborty, Debashis
AU - Shajahan, Shanavas
AU - Abu Haija, Mohammad
N1 - Funding Information:
The authors wish to acknowledge the analytical support from the IIT Madras. The authors S.S. and M.A.H. are grateful to the Khalifa University of Science and Technology for supporting this study under CIRA-2020-085. Author S.P. greatly appreciates the support of the Lady Davis excellence fellowship.
Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society.
PY - 2022
Y1 - 2022
N2 - This work describes a one-pot synthesis of dendrite-like hyperbranched polyglycerols (HPGs) via a ring-opening multibranching polymerization (ROMBP) process using a bis(5,7-dichloro-2-methyl-8-quinolinolato)methyl aluminum complex (1) as a catalyst and 1,1,1-tris(hydroxymethyl)propane/trimethylol propane (TMP) as an initiator. Single-crystal X-ray diffraction (XRD) analysis was used to elucidate the molecular structure of complex 1. Inverse-gated (IG)13C NMR analysis of HPGs showed degree of branching between 0.50 and 0.57. Gel permeation chromatography (GPC) analysis of the HPG polymers provided low, medium, and high-molecular weight (Mn) polymers ranging from 14 to 73 kDa and molecular weight distributions (Mw/Mn) between 1.16 and 1.35. The obtained HPGs exhibited high wettability with water contact angle between 18 and 21° and Tg ranging between -39 and -55 °C. Notably, ancillary ligand-supported aluminum complexes as catalysts for HPG polymerization reactions have not been reported to date. The obtained HPG polymers in the presence of the aluminum complex (1) can be used for various biomedical applications. Here, nanocomposite electrospun fibers were fabricated with synthesized HPG polymer. The nanofibers were subjected to cell culture experiments to evaluate cytocompatibility behavior with L929 and MG63 cells. The cytocompatibility studies of HPG polymer and nanocomposite scaffold showed high cell viability and spreading. The study results concluded, synthesized HPG polymers and composite nanofibers can be used for various biomedical applications.
AB - This work describes a one-pot synthesis of dendrite-like hyperbranched polyglycerols (HPGs) via a ring-opening multibranching polymerization (ROMBP) process using a bis(5,7-dichloro-2-methyl-8-quinolinolato)methyl aluminum complex (1) as a catalyst and 1,1,1-tris(hydroxymethyl)propane/trimethylol propane (TMP) as an initiator. Single-crystal X-ray diffraction (XRD) analysis was used to elucidate the molecular structure of complex 1. Inverse-gated (IG)13C NMR analysis of HPGs showed degree of branching between 0.50 and 0.57. Gel permeation chromatography (GPC) analysis of the HPG polymers provided low, medium, and high-molecular weight (Mn) polymers ranging from 14 to 73 kDa and molecular weight distributions (Mw/Mn) between 1.16 and 1.35. The obtained HPGs exhibited high wettability with water contact angle between 18 and 21° and Tg ranging between -39 and -55 °C. Notably, ancillary ligand-supported aluminum complexes as catalysts for HPG polymerization reactions have not been reported to date. The obtained HPG polymers in the presence of the aluminum complex (1) can be used for various biomedical applications. Here, nanocomposite electrospun fibers were fabricated with synthesized HPG polymer. The nanofibers were subjected to cell culture experiments to evaluate cytocompatibility behavior with L929 and MG63 cells. The cytocompatibility studies of HPG polymer and nanocomposite scaffold showed high cell viability and spreading. The study results concluded, synthesized HPG polymers and composite nanofibers can be used for various biomedical applications.
UR - http://www.scopus.com/inward/record.url?scp=85146157774&partnerID=8YFLogxK
U2 - 10.1021/acsomega.2c06761
DO - 10.1021/acsomega.2c06761
M3 - Article
AN - SCOPUS:85146157774
SN - 2470-1343
JO - ACS Omega
JF - ACS Omega
ER -