Complexity of heart rate variability in type 2 diabetes - Effect of hyperglycemia

Mika P. Tarvainen; David J. Cornforth; Pekka Kuoppa; Jukka A. Lipponen; Herbert F. Jelinek

doi:10.1109/EMBC.2013.6610809

Complexity of heart rate variability in type 2 diabetes - Effect of hyperglycemia

Mika P. Tarvainen
, David J. Cornforth
, Pekka Kuoppa
, Jukka A. Lipponen
, Herbert F. Jelinek

Biomedical Engineering & Biotechnology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

17 Scopus citations

Abstract

Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation which has been associated with increased risk for pathological cardiac events. In this paper, we examined changes in HRV complexity in association to blood glucose level (BGL) and duration of diabetes. Resting HRV and BGL measurements of 32 healthy controls and 54 type 2 DM (T2DM) patients were analyzed. HRV complexity was assessed using Shannon entropy, sample entropy (SampEn), multiscale entropy (MSE), and multiscale Renyi entropy. HRV complexity increased with hyperglycemia indicated by increases in Shannon entropy and MSE and decreases in Renyi entropy for negative orders. Diabetes duration was strongly associated with Renyi entropy which increased for positive orders and decreased for negative orders as a function of disease duration. Shannon entropy, SampEn and MSE did not correlate with disease duration.

Original language	British English
Title of host publication	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages	5558-5561
Number of pages	4
DOIs	https://doi.org/10.1109/EMBC.2013.6610809
State	Published - 2013
Event	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan Duration: 3 Jul 2013 → 7 Jul 2013

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Conference

Conference	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Country/Territory	Japan
City	Osaka
Period	3/07/13 → 7/07/13

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1109/EMBC.2013.6610809

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Tarvainen, M. P., Cornforth, D. J., Kuoppa, P., Lipponen, J. A., & Jelinek, H. F. (2013). Complexity of heart rate variability in type 2 diabetes - Effect of hyperglycemia. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 (pp. 5558-5561). Article 6610809 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6610809

Tarvainen, Mika P. ; Cornforth, David J. ; Kuoppa, Pekka et al. / Complexity of heart rate variability in type 2 diabetes - Effect of hyperglycemia. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. pp. 5558-5561 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Complexity of heart rate variability in type 2 diabetes - Effect of hyperglycemia",

abstract = "Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation which has been associated with increased risk for pathological cardiac events. In this paper, we examined changes in HRV complexity in association to blood glucose level (BGL) and duration of diabetes. Resting HRV and BGL measurements of 32 healthy controls and 54 type 2 DM (T2DM) patients were analyzed. HRV complexity was assessed using Shannon entropy, sample entropy (SampEn), multiscale entropy (MSE), and multiscale Renyi entropy. HRV complexity increased with hyperglycemia indicated by increases in Shannon entropy and MSE and decreases in Renyi entropy for negative orders. Diabetes duration was strongly associated with Renyi entropy which increased for positive orders and decreased for negative orders as a function of disease duration. Shannon entropy, SampEn and MSE did not correlate with disease duration.",

author = "Tarvainen, \{Mika P.\} and Cornforth, \{David J.\} and Pekka Kuoppa and Lipponen, \{Jukka A.\} and Jelinek, \{Herbert F.\}",

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Tarvainen, MP, Cornforth, DJ, Kuoppa, P, Lipponen, JA & Jelinek, HF 2013, Complexity of heart rate variability in type 2 diabetes - Effect of hyperglycemia. in 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013., 6610809, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 5558-5561, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 3/07/13. https://doi.org/10.1109/EMBC.2013.6610809

Complexity of heart rate variability in type 2 diabetes - Effect of hyperglycemia. / Tarvainen, Mika P.; Cornforth, David J.; Kuoppa, Pekka et al.
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 5558-5561 6610809 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Heart rate variability (HRV) is reduced in diabetes mellitus (DM) patients, suggesting dysfunction of cardiac autonomic regulation which has been associated with increased risk for pathological cardiac events. In this paper, we examined changes in HRV complexity in association to blood glucose level (BGL) and duration of diabetes. Resting HRV and BGL measurements of 32 healthy controls and 54 type 2 DM (T2DM) patients were analyzed. HRV complexity was assessed using Shannon entropy, sample entropy (SampEn), multiscale entropy (MSE), and multiscale Renyi entropy. HRV complexity increased with hyperglycemia indicated by increases in Shannon entropy and MSE and decreases in Renyi entropy for negative orders. Diabetes duration was strongly associated with Renyi entropy which increased for positive orders and decreased for negative orders as a function of disease duration. Shannon entropy, SampEn and MSE did not correlate with disease duration.

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Tarvainen MP, Cornforth DJ, Kuoppa P, Lipponen JA, Jelinek HF. Complexity of heart rate variability in type 2 diabetes - Effect of hyperglycemia. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 5558-5561. 6610809. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2013.6610809

Complexity of heart rate variability in type 2 diabetes - Effect of hyperglycemia

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