@inproceedings{b8c72c003db2413cb010f0805f0542ff,
title = "Complex correlation measure as a sensitive indicator of risk for sudden cardiac death in patients with depression",
abstract = "Heart rate variability (HRV) is reduced in patients with Major Depressive Disorder (MDD). We examined the sensitivity of a new nonlinear parameter, the Complex Correlation Measure (CCM) in patients with depression. Two-minute ECG recordings at rest with eyes-closed were analyzed. CCM was higher (0.36±0.1) in control participants compared to MDD (0.29±0.1), indicating a decrease in temporal variability associated with decreased parasympathetic function (Cohen's d = 0.7, p=0.0008). CCM also demonstrated a larger effect size than SD1 (Cohen's d = 0.5, p =0.0005) and SD2 (Cohen's d = 0.2, p = 0.015). These results highlight that depressed patients display a dampening of oscillations between parasympathetic and sympathetic input indicative of reduced functionality and increased risk of sudden cardiac death. CCM is a more sensitive measure of HRV, which provides additional information on HRV dynamics compared to SD1 and SD2 of the Poincar{\'e} plot distribution.",
author = "Jelinek, {Herbert F.} and Khandoker, {Ahsan H.} and Quintana, {D. S.} and Imam, {Md Hasan} and Kemp, {A. H.}",
year = "2011",
language = "British English",
isbn = "9781457706127",
series = "Computing in Cardiology",
pages = "809--812",
booktitle = "Computing in Cardiology 2011, CinC 2011",
note = "Computing in Cardiology 2011, CinC 2011 ; Conference date: 18-09-2011 Through 21-09-2011",
}