Co-occurrence of autoantibodies in healthy blood donors

Jasper Prüßmann, Wiebke Prüßmann, Andreas Recke, Kristin Rentzsch, David Juhl, Reinhard Henschler, Susen Müller, Peter Lamprecht, Enno Schmidt, Elena Csernok, Siegfried Görg, Winfried Stöcker, Detlef Zillikens, Saleh M. Ibrahim, Ralf J. Ludwig

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA-positive compared to ANA-negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens.

Original languageBritish English
Pages (from-to)519-521
Number of pages3
JournalExperimental Dermatology
Volume23
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • Autoantibodies
  • Autoimmune disease
  • Autoimmunity
  • Blood donor
  • Health

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