Co-occurrence of autoantibodies in healthy blood donors

Jasper Prüßmann; Wiebke Prüßmann; Andreas Recke; Kristin Rentzsch; David Juhl; Reinhard Henschler; Susen Müller; Peter Lamprecht; Enno Schmidt; Elena Csernok; Siegfried Görg; Winfried Stöcker; Detlef Zillikens; Saleh M. Ibrahim; Ralf J. Ludwig

doi:10.1111/exd.12445

Co-occurrence of autoantibodies in healthy blood donors

Jasper Prüßmann, Wiebke Prüßmann, Andreas Recke, Kristin Rentzsch, David Juhl, Reinhard Henschler, Susen Müller, Peter Lamprecht, Enno Schmidt, Elena Csernok, Siegfried Görg, Winfried Stöcker, Detlef Zillikens, Saleh M. Ibrahim, Ralf J. Ludwig

College of Medicine and Health Sciences

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA-positive compared to ANA-negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens.

Original language	British English
Pages (from-to)	519-521
Number of pages	3
Journal	Experimental Dermatology
Volume	23
Issue number	7
DOIs	https://doi.org/10.1111/exd.12445
State	Published - Jul 2014

Keywords

Autoantibodies
Autoimmune disease
Autoimmunity
Blood donor
Health

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10.1111/exd.12445

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title = "Co-occurrence of autoantibodies in healthy blood donors",

abstract = "Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA-positive compared to ANA-negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens.",

keywords = "Autoantibodies, Autoimmune disease, Autoimmunity, Blood donor, Health",

author = "Jasper Pr{\"u}{\ss}mann and Wiebke Pr{\"u}{\ss}mann and Andreas Recke and Kristin Rentzsch and David Juhl and Reinhard Henschler and Susen M{\"u}ller and Peter Lamprecht and Enno Schmidt and Elena Csernok and Siegfried G{\"o}rg and Winfried St{\"o}cker and Detlef Zillikens and Ibrahim, {Saleh M.} and Ludwig, {Ralf J.}",

year = "2014",

month = jul,

doi = "10.1111/exd.12445",

language = "British English",

volume = "23",

pages = "519--521",

journal = "Experimental Dermatology",

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AU - Prüßmann, Jasper

AU - Prüßmann, Wiebke

AU - Recke, Andreas

AU - Rentzsch, Kristin

AU - Juhl, David

AU - Henschler, Reinhard

AU - Müller, Susen

AU - Lamprecht, Peter

AU - Schmidt, Enno

AU - Csernok, Elena

AU - Görg, Siegfried

AU - Stöcker, Winfried

AU - Zillikens, Detlef

AU - Ibrahim, Saleh M.

AU - Ludwig, Ralf J.

PY - 2014/7

Y1 - 2014/7

N2 - Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA-positive compared to ANA-negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens.

AB - Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA-positive compared to ANA-negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens.

KW - Autoantibodies

KW - Autoimmune disease

KW - Autoimmunity

KW - Blood donor

KW - Health

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Co-occurrence of autoantibodies in healthy blood donors

Abstract

Keywords

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