Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field

Sahan C.B. Herath; Yue Du; Dong an Wang; Kin Liao; Qingguo Wang; Harry Asada; Peter C.Y. Chen

doi:10.1016/j.jmbbm.2013.11.012

Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field

Sahan C.B. Herath
, Yue Du
, Dong an Wang
, Kin Liao
, Qingguo Wang
, Harry Asada
, Peter C.Y. Chen

Aerospace Engineering

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In this paper, we study the deformation, and experimentally quantify the change in stiffness, of an extracellular matrix (ECM) embedded with magnetic beads that are bio-conjugated with the collagen fibers and under the influence of an external magnetic field. We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field. The analytical results are in close agreement with that obtained from the experiments. We discuss the implication of these results that point to the possibility of creating desired stiffness gradients in an ECM in vitro to influence cell behavior.

Original language	British English
Pages (from-to)	253-265
Number of pages	13
Journal	Journal of the Mechanical Behavior of Biomedical Materials
Volume	30
DOIs	https://doi.org/10.1016/j.jmbbm.2013.11.012
State	Published - Feb 2014

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10.1016/j.jmbbm.2013.11.012

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Herath, S. C. B., Du, Y., Wang, D. A., Liao, K., Wang, Q., Asada, H., & Chen, P. C. Y. (2014). Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field. Journal of the Mechanical Behavior of Biomedical Materials, 30, 253-265. https://doi.org/10.1016/j.jmbbm.2013.11.012

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title = "Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field",

abstract = "In this paper, we study the deformation, and experimentally quantify the change in stiffness, of an extracellular matrix (ECM) embedded with magnetic beads that are bio-conjugated with the collagen fibers and under the influence of an external magnetic field. We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field. The analytical results are in close agreement with that obtained from the experiments. We discuss the implication of these results that point to the possibility of creating desired stiffness gradients in an ECM in vitro to influence cell behavior.",

author = "Herath, \{Sahan C.B.\} and Yue Du and Wang, \{Dong an\} and Kin Liao and Qingguo Wang and Harry Asada and Chen, \{Peter C.Y.\}",

note = "Funding Information: The authors would like to thank the BioSystem and Micromechanics Interdisciplinary Research Group (under the Singapore-MIT Alliance for Research and Technology Program) for their financial support. The first author would like to acknowledge the financial support provided by the National University of Singapore . The second author also would like to acknowledge the financial support provided by the China Scholarship Council and the National University of Singapore. ",

year = "2014",

month = feb,

doi = "10.1016/j.jmbbm.2013.11.012",

language = "British English",

volume = "30",

pages = "253--265",

journal = "Journal of the Mechanical Behavior of Biomedical Materials",

issn = "1751-6161",

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}

Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field. / Herath, Sahan C.B.; Du, Yue; Wang, Dong an et al.
In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 30, 02.2014, p. 253-265.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field

AU - Herath, Sahan C.B.

AU - Du, Yue

AU - Wang, Dong an

AU - Liao, Kin

AU - Wang, Qingguo

AU - Asada, Harry

AU - Chen, Peter C.Y.

N1 - Funding Information: The authors would like to thank the BioSystem and Micromechanics Interdisciplinary Research Group (under the Singapore-MIT Alliance for Research and Technology Program) for their financial support. The first author would like to acknowledge the financial support provided by the National University of Singapore . The second author also would like to acknowledge the financial support provided by the China Scholarship Council and the National University of Singapore.

PY - 2014/2

Y1 - 2014/2

N2 - In this paper, we study the deformation, and experimentally quantify the change in stiffness, of an extracellular matrix (ECM) embedded with magnetic beads that are bio-conjugated with the collagen fibers and under the influence of an external magnetic field. We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field. The analytical results are in close agreement with that obtained from the experiments. We discuss the implication of these results that point to the possibility of creating desired stiffness gradients in an ECM in vitro to influence cell behavior.

AB - In this paper, we study the deformation, and experimentally quantify the change in stiffness, of an extracellular matrix (ECM) embedded with magnetic beads that are bio-conjugated with the collagen fibers and under the influence of an external magnetic field. We develop an analytical model of the viscoelastic behavior of this modified ECM, and design and implement a stretch test to quantify (based on statistically meaningful experiment data) the resulting changes in its stiffness induced by the external magnetic field. The analytical results are in close agreement with that obtained from the experiments. We discuss the implication of these results that point to the possibility of creating desired stiffness gradients in an ECM in vitro to influence cell behavior.

UR - https://www.scopus.com/pages/publications/84890323072

U2 - 10.1016/j.jmbbm.2013.11.012

DO - 10.1016/j.jmbbm.2013.11.012

M3 - Article

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AN - SCOPUS:84890323072

SN - 1751-6161

VL - 30

SP - 253

EP - 265

JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

ER -

Characterization of uniaxial stiffness of extracellular matrix embedded with magnetic beads via bio-conjugation and under the influence of an external magnetic field

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