TY - JOUR
T1 - Challenges and recent trends with the development of hydrogel fiber for biomedical applications
AU - Ansar, Reema
AU - Saqib, Sidra
AU - Mukhtar, Ahmad
AU - Niazi, Muhammad Bilal Khan
AU - Shahid, Muhammad
AU - Jahan, Zaib
AU - Kakar, Salik Javed
AU - Uzair, Bushra
AU - Mubashir, Muhammad
AU - Ullah, Sami
AU - Khoo, Kuan Shiong
AU - Lim, Hooi Ren
AU - Show, Pau Loke
N1 - Funding Information:
The authors would like to acknowledge the Department of Chemical Engineering, University of Gujrat, Pakistan and School of Chemical and Materials Engineering, National University of Sciences and Technology, Islamabad, Pakistan. The authors are also thankful to the Deanship of Scientific Research at King Khalid University for partially supporting this research under grant number RGP.1/73/42.
Funding Information:
The authors would like to acknowledge the Department of Chemical Engineering, University of Gujrat, Pakistan and School of Chemical and Materials Engineering, National University of Sciences and Technology, Islamabad, Pakistan. The authors are also thankful to the Deanship of Scientific Research at King Khalid University for partially supporting this research under grant number RGP.1/73/42 .
Publisher Copyright:
© 2021
PY - 2022/1
Y1 - 2022/1
N2 - Hydrogel is the most emblematic soft material which possesses significantly tunable and programmable characteristics. Polymer hydrogels possess significant advantages including, biocompatible, simple, reliable and low cost. Therefore, research on the development of hydrogel for biomedical applications has been grown intensely. However, hydrogel development is challenging and required significant effort before the application at an industrial scale. Therefore, the current work focused on evaluating recent trends and issues with hydrogel development for biomedical applications. In addition, the hydrogel's development methodology, physicochemical properties, and biomedical applications are evaluated and benchmarked against the reported literature. Later, biomedical applications of the nano-cellulose-based hydrogel are considered and critically discussed. Based on a detailed review, it has been found that the surface energy, intermolecular interactions, and interactions of hydrogel adhesion forces are major challenges that contribute to the development of hydrogel. In addition, compared to other hydrogels, nanocellulose hydrogels demonstrated higher potential for drug delivery, 3D cell culture, diagnostics, tissue engineering, tissue therapies and gene therapies. Overall, nanocellulose hydrogel has the potential for commercialization for different biomedical applications.
AB - Hydrogel is the most emblematic soft material which possesses significantly tunable and programmable characteristics. Polymer hydrogels possess significant advantages including, biocompatible, simple, reliable and low cost. Therefore, research on the development of hydrogel for biomedical applications has been grown intensely. However, hydrogel development is challenging and required significant effort before the application at an industrial scale. Therefore, the current work focused on evaluating recent trends and issues with hydrogel development for biomedical applications. In addition, the hydrogel's development methodology, physicochemical properties, and biomedical applications are evaluated and benchmarked against the reported literature. Later, biomedical applications of the nano-cellulose-based hydrogel are considered and critically discussed. Based on a detailed review, it has been found that the surface energy, intermolecular interactions, and interactions of hydrogel adhesion forces are major challenges that contribute to the development of hydrogel. In addition, compared to other hydrogels, nanocellulose hydrogels demonstrated higher potential for drug delivery, 3D cell culture, diagnostics, tissue engineering, tissue therapies and gene therapies. Overall, nanocellulose hydrogel has the potential for commercialization for different biomedical applications.
KW - Biomedical applications
KW - Hydrogels
KW - Nano-cellulose
KW - Nanocrystals
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85114313012&partnerID=8YFLogxK
U2 - 10.1016/j.chemosphere.2021.131956
DO - 10.1016/j.chemosphere.2021.131956
M3 - Article
C2 - 34523459
AN - SCOPUS:85114313012
SN - 0045-6535
VL - 287
JO - Chemosphere
JF - Chemosphere
M1 - 131956
ER -
