CCK-8 can inhibit ingestive behavior by acting on the liver

M. Qian; G. S. Wu; A. Adem; A. E. Johnson; P. Södersten

doi:10.1097/00001756-199902050-00027

CCK-8 can inhibit ingestive behavior by acting on the liver

M. Qian, G. S. Wu, A. Adem, A. E. Johnson, P. Södersten

College of Medicine and Health Sciences

Karolinska Inst., Novum, KFC, P.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

THE possibility that cholecystokinin octapeptide (CCK8) can inhibit ingestive behavior by acting on the liver was investigated. Male rats were trained to ingest an intraorally infused 1M solution of sucrose and then injected with 10 μg CCK-8/kg. Intraperitoneal or hepatic portal vein, but not jugular vein, injection suppressed intake of the sucrose solution. Intraperitoneal injection was more potent than hepatic portal vein injection. Inhibition by hepatic portal vein injection was blocked by i.p. injection of 80 μg/kg of the CCK-A receptor antagonist L-364,718 or by hepatic vagotomy. The results support the hypothesis that CCK-8 can inhibit ingestive behavior via a hormonal action on the liver.

Original language	British English
Pages (from-to)	359-362
Number of pages	4
Journal	NeuroReport
Volume	10
Issue number	2
DOIs	https://doi.org/10.1097/00001756-199902050-00027
State	Published - 5 Feb 1999

Keywords

Cholecystokinin
Food intake
Hormonal action
Liver
Male rats

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10.1097/00001756-199902050-00027

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title = "CCK-8 can inhibit ingestive behavior by acting on the liver",

abstract = "THE possibility that cholecystokinin octapeptide (CCK8) can inhibit ingestive behavior by acting on the liver was investigated. Male rats were trained to ingest an intraorally infused 1M solution of sucrose and then injected with 10 μg CCK-8/kg. Intraperitoneal or hepatic portal vein, but not jugular vein, injection suppressed intake of the sucrose solution. Intraperitoneal injection was more potent than hepatic portal vein injection. Inhibition by hepatic portal vein injection was blocked by i.p. injection of 80 μg/kg of the CCK-A receptor antagonist L-364,718 or by hepatic vagotomy. The results support the hypothesis that CCK-8 can inhibit ingestive behavior via a hormonal action on the liver.",

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T1 - CCK-8 can inhibit ingestive behavior by acting on the liver

AU - Qian, M.

AU - Wu, G. S.

AU - Adem, A.

AU - Johnson, A. E.

AU - Södersten, P.

PY - 1999/2/5

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N2 - THE possibility that cholecystokinin octapeptide (CCK8) can inhibit ingestive behavior by acting on the liver was investigated. Male rats were trained to ingest an intraorally infused 1M solution of sucrose and then injected with 10 μg CCK-8/kg. Intraperitoneal or hepatic portal vein, but not jugular vein, injection suppressed intake of the sucrose solution. Intraperitoneal injection was more potent than hepatic portal vein injection. Inhibition by hepatic portal vein injection was blocked by i.p. injection of 80 μg/kg of the CCK-A receptor antagonist L-364,718 or by hepatic vagotomy. The results support the hypothesis that CCK-8 can inhibit ingestive behavior via a hormonal action on the liver.

AB - THE possibility that cholecystokinin octapeptide (CCK8) can inhibit ingestive behavior by acting on the liver was investigated. Male rats were trained to ingest an intraorally infused 1M solution of sucrose and then injected with 10 μg CCK-8/kg. Intraperitoneal or hepatic portal vein, but not jugular vein, injection suppressed intake of the sucrose solution. Intraperitoneal injection was more potent than hepatic portal vein injection. Inhibition by hepatic portal vein injection was blocked by i.p. injection of 80 μg/kg of the CCK-A receptor antagonist L-364,718 or by hepatic vagotomy. The results support the hypothesis that CCK-8 can inhibit ingestive behavior via a hormonal action on the liver.

KW - Cholecystokinin

KW - Food intake

KW - Hormonal action

KW - Liver

KW - Male rats

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CCK-8 can inhibit ingestive behavior by acting on the liver

Abstract

Keywords

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